Overview of Cryptosporidium Presentations at the 10th International Workshops on Opportunistic Protists
Overview of Cryptosporidium Presentations at the 10th International Workshops on Opportunistic Protists
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DOI：
10.1128/ec.00295-08
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Xiao, Lihua
中科院分区：
文献类型：
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作者：
Xiao, Lihua
自1907年美国著名微生物学家欧内斯特·E·泰泽在家鼠胃中发现隐孢子虫以来(58)，自1976年将隐孢子虫鉴定为人类病原体(38，40)以来，已有30多年的历史。隐孢子虫病仍然是人类免疫缺陷病毒阳性患者的一种重要的机会性病原体。这在很大程度上是由于发展中国家使用的高度有效的抗逆转录病毒疗法有限，而且免疫受损的人缺乏有效的治疗寄生虫的药物。目前对隐孢子虫病的研究主要集中在利用分子诊断工具对环境生态、感染源和危险因素进行表征，识别寄生虫独特的生化和代谢途径以进行药物开发，以及阐明免疫反应和发病机制。最近完成了微小隐孢子虫、人隐孢子虫和小鼠隐孢子虫的全基因组测序，极大地促进了这些工作。在第十届机会主义原生生物国际研讨会(IWOP-10)上提出的26项研究报告清楚地反映了当前隐孢子虫病研究的趋势。
It has been over 100 years since the discovery of Cryptosporidium in the stomachs of house mice by the prominent American microbiologist Ernest E. Tyzzer in 1907 (58) and over 30 years since the identification of Cryptosporidium as a human pathogen in 1976 (38, 40). Cryptosporidiosis remains an important opportunistic pathogen in human immunodeficiency virus-positive persons. This is due largely to the limited use of highly active antiretroviral therapy in developing countries and the lack of an effective drug against the parasite in immunocompromised persons. Recent research efforts in cryptosporidiosis are directed largely at characterizations of environmental ecology, infection source, and risk factors using molecular diagnostic tools, identifications of parasite-unique biochemical and metabolic pathways for drug development, and elucidations of immune responses and pathogenesis. These efforts have been greatly facilitated by the recent completion of whole-genome sequencing of Cryptosporidium parvum, Cryptosporidium hominis, and Cryptosporidium muris. The26 research studies presented at the 10th International Workshop on Opportunistic Protists (IWOP-10) clearly reffected the current trends in cryptosporidiosis research.