Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation
Serum vascular endothelial growth factor is elevated in cystic fibrosis and decreases with treatment of acute pulmonary exacerbation
复制标题
DOI：
10.1164/ajrccm.161.6.9905022
复制
发表时间：
2000-06-01
影响因子：
24.7
通讯作者：
Crawford, SE
中科院分区：
文献类型：
--
作者：
McColley, SA;Stellmach, V;Crawford, SE
慢性细菌感染和嗜酸性炎症是囊性纤维化（CF）肺病的特征。在许多疾病中，炎症和血管生成是相互依赖的现象。我们以前注意到CF组织中过度的血管生成和CF受试者随机血清样本中血管内皮生长因子（VEGF）升高。为了进一步探讨这一发现，我们检测了38例稳定CF患者和25例其他肺部疾病患者的血清VEGF。与参考值相比，两组的平均VEGF均升高，但CF组更高：403 +/- 280 vs 255 +/- 169 pg/ml，p = 0.02。VEGF与FEV呈负相关，CF中，r =-0.51，p = 0.007。为了评估呼吸道感染对VEGF的影响，研究了10名CF受试者在静脉内抗生素治疗肺恶化之前和之后的情况。VEGF水平随着抗生素治疗而降低，从537 +/- 220降至259 +/- 176 pg/ml，p = 0.001。我们的结论是，循环血管内皮生长因子在CF和其他炎症性肺部疾病的受试者增加。在CF中，VEGF升高与气道感染有关。我们推测，循环中VEGF的增加与慢性炎症有关，这在CF中很明显。升高的循环VEGF可能导致组织血管生成，促进肺部疾病的进展。
Chronic bacterial infection and neutrophilic inflammation characterize cystic fibrosis (CF) pulmonary disease. In many disorders, inflammation and angiogenesis are codependent phenomena. We previously noted excessive angiogenesis in CF tissues and elevated vascular endothelial growth factor (VEGF) in random serum samples from subjects with CF. To further explore this finding, we measured serum VEGF in 38 subjects with stable CF and in 25 subjects with other pulmonary diseases. Mean VEGF was elevated in both groups compared with reference values, but it was higher in CF: 403 +/- 280 versus 255 +/- 169 pg/ml, p = 0.02. VEGF was negatively correlated with FEV, in CF, r = -0.51, p = 0.007. To assess the effect of airway infection on VEGF, 10 subjects with CF were studied before and after intravenous antibiotic therapy for pulmonary exacerbation. VEGF levels decreased with antibiotic: therapy, from 537 +/- 220 to 259 +/- 176 pg/ml, p = 0.001. We conclude that circulating VEGF is increased in subjects with CF and other inflammatory pulmonary disorders. In CF, VEGF elevation is related to airway infection. We speculate that increased circulating VEGF is related to chronic inflammation, which is robust in CF. Elevated circulating VEGF may result in tissue angiogenesis, furthering the progression of pulmonary disease.