The Cholinergic System in the Chicken Retina: Cellular Localization and Development
The Cholinergic System in the Chicken Retina: Cellular Localization and Development
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鸡视网膜中的胆碱能系统：细胞定位和发育
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
R. Baughman
中科院分区：
文献类型：
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作者：
R. Baughman
鸡视网膜胆碱能系统的细胞定位，确定通过冷冻干燥和干放射自显影孵育后，[3 H]胆碱的条件下，有利于高亲和力摄取。胆碱能细胞分布于内核层和神经节细胞层，并在内丛状层呈两条带状延伸。在鸡胚胎发生过程中，胆碱能系统的发育分为两个阶段：第一阶段发生在视网膜分化的相对早期，与ACh合成和贮存的增加以及CAT活性的大幅度升高有关;第二次发生在孵化前，与突触发生和视觉功能的出现一致，并与乙酰胆碱合成和储存的进一步增加以及高亲和力胆碱摄取的发展有关。
The cellular localization of the cholinergic system of the chicken retina was determined by means of freeze-drying and dry autoradiography following incubation with [3H]choline under conditions favoring high-affinity uptake. The cholinergic cells were localized to the inner nuclear and ganglion cell layers, and they extended processes in two bands in the inner plexiform layer. During embryogenesis in the chick, the cholinergic system was found to develop in two stages; the first occurs relatively early in retinal differentiation and is associated with increased ACh synthesis and storage and with a large rise in CAT activity; and the second occurs just before hatching, coincident with synaptogenesis and the appearance of visual function, and is associated with further increases in ACh synthesis and storage and with the development of high-affinity choline uptake.