The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: Therapeutic implications of low-dose methylphenidate
The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: Therapeutic implications of low-dose methylphenidate
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DOI：
10.1016/j.bbr.2014.08.026
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发表时间：
2014-11-01
影响因子：
2.7
通讯作者：
Nishi, Akinori
中科院分区：
文献类型：
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作者：
Kishikawa, Yuki;Kawahara, Yukie;Nishi, Akinori
自发性高血压大鼠（SHR）已被用作注意缺陷多动障碍（ADHD）的遗传动物模型。SHR/Izm来源于卒中抗性SHR，如SHR/NIH和SHR/NCrl，但来自SHR/NIH祖先的第22至23代后代，因此与其他SHR亚株相比可能显示出不同的行为表型。在这项研究中，ADHD样行为在SHR/Izm进行了评估相比，Wistar大鼠。SHR/Izm在新环境中的习惯化阶段表现出较高的运动活性，尽管在初始探索阶段的运动活性较低。在注意力的行为测试中，自发交替行为在Y-迷宫测试中在SHR/Izm中受损。然而，高架十字迷宫测试中的冲动行为与Wistar大鼠相当，该测试旨在检测焦虑相关行为，但也反映了寻求新奇的冲动。多动和注意力不集中，检测为ADHD的行为在SHR/Izm，改善哌甲酯在低剂量（0.05 mg/kg，腹腔注射）。因此，SHR/Izm代表了一种独特的ADHD动物模型，没有焦虑相关的冲动行为。(C)© 2014 Elsevier B. V.保留所有权利。
The spontaneously hypertensive rat (SHR) has been used as a genetic animal model of attention deficit/hyperactivity disorder (ADHD). SHR/Izm is derived from stroke-resistant SHR as SHR/NIH and SHR/NCrl but from 22nd to 23rd generation descendants of the SHR/NIH ancestor and therefore may show different behavioral phenotypes compared to other SHR sub-strains. In this study, ADHD-like behaviors in SHR/Izm were evaluated compared to Wistar rats. SHR/Izm showed high locomotor activity in the habituation phase in a novel environment, although locomotor activity in the initial exploratory phase was low. In a behavioral test for attention, spontaneous alternation behavior in the Y-maze test was impaired in SHR/Izm. However, impulsive behavior in the elevated-plus maze test, which is designed to detect anxiety-related behavior but also reflects impulsivity for novelty seeking, was comparable to Wistar rats. Hyperactivity and inattention, detected as ADHD-like behaviors in SHR/Izm, were ameliorated with methylphenidate at a low dose (0.05 mg/kg, i.p.). Therefore, SHR/Izm represents a unique animal model of ADHD without anxiety-related impulsive behavior. (C) 2014 Elsevier B.V. All rights reserved.