An fMRI study of joint attention experience
An fMRI study of joint attention experience
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DOI：
10.1016/j.neuroimage.2004.10.047
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发表时间：
2005-03-01
期刊：
影响因子：
5.7
通讯作者：
Whiten, A
中科院分区：
文献类型：
--
作者：
Williams, JHG;Waiter, GD;Whiten, A
虽然现在对眼动检测了解很多，但对联合注意中涉及的高级认知过程知之甚少。我们开发了视频刺激，当观看时，在观察者中产生联合注意力的体验。这使我们能够在功能磁共振成像扫描环境中比较联合注意和非联合注意的体验。联合注意力与腹内侧额叶皮层、左额上级回（BA 10）、扣带回皮层和尾状核的活动有关。在心理状态归因任务中，腹内侧额叶皮层一直被激活。BA 10可以服务于认知整合功能，在这种情况下，其似乎利用感知-动作匹配过程。我们在BA 10中发现的激活与我们最近发现的与自闭症谱系障碍相关的灰质密度增加的位置重叠。因此，这项研究构成的证据表明，联合注意的神经基板也提供了一个心智化功能。左前额叶中这种基质的发育失败可能在自闭症谱系障碍的病因学中很重要。(C)2004年爱思唯尔公司All rights reserved.
Although much is now known about eye movement detection, little is known about the higher cognitive processes involved in joint attention. We developed video stimuli which when watched, engender an experience of joint attention in the observer. This allowed us to compare an experience of joint attention to nonjoint attention within an fMRI scanning environment. Joint attention was associated with activity in the ventromedial frontal cortex, the left superior frontal gyrus (BA10), cingulate cortex, and caudate nuclei. The ventromedial frontal cortex has been consistently shown to be activated during mental state attribution tasks. BA10 may serve a cognitive integration function, which in this case seems to utilize a perception-action matching process. The activation we identified in BA10 overlaps with a location of increased grey matter density that we recently found to be associated with autistic spectrum disorder. This study therefore constitutes evidence that the neural substrate of joint attention also serves a mentalizing function. The developmental failure of this substrate in the left anterior frontal lobe may be important in the etiology of autistic spectrum disorder. (C) 2004 Elsevier Inc. All rights reserved.