Direct Evidence of Nitric Oxide Production in Guinea Pig Vestibular Sensory Cells
Direct Evidence of Nitric Oxide Production in Guinea Pig Vestibular Sensory Cells
复制标题
豚鼠前庭感觉细胞产生一氧化氮的直接证据
DOI：
10.1080/000164800760370800
复制
发表时间：
2000
影响因子：
1.4
通讯作者：
M. Anniko
中科院分区：
文献类型：
--
作者：
M. Anniko
采用新型荧光指示剂DAF-2DA直接检测豚鼠前庭器官一氧化氮（NO）的产生。检测室斑和离体前庭感觉细胞定位一氧化氮产生位点。l -精氨酸刺激后感觉细胞的荧光强度增强，接种LPS后荧光强度显著增强。这是在前庭末端器官产生一氧化氮的第一个直接证据。一氧化氮可能在前庭生理学中起重要作用，也参与内耳疾病。
Production of nitric oxide (NO) in the vestibular organ of the guinea pig was investigated using the new fluorescence indicator, DAF-2DA, for direct detection of NO. The utricular maculae and isolated vestibular sensory cells were examined to locate NO production sites. The fluorescence intensity of the sensory cells was augmented by stimulation with L-arginine, and significantly increased after inoculation with LPS. This is the first direct evidence of NO production in the vestibular end organs. NO may play an important role for the vestibular physiology and also be involved in disease of the inner ear.
一氧化氮、超氧化物和过氧亚硝酸盐：好的、坏的和丑陋的。
DOI：
10.1152/ajpcell.1996.271.5.c1424
发表时间：
1996
期刊：
The American journal of physiology
影响因子：
--
作者：
Beckman,JS;Koppenol,WH
通讯作者：
Koppenol,WH