Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans.
Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans.
复制标题
人类鼻内给药后催产素的脑脊液和血液浓度升高
DOI：
10.1038/srep03440
复制
发表时间：
2013-12-06
影响因子：
4.6
通讯作者：
Hurlemann R
中科院分区：
文献类型：
--
作者：
Striepens N;Kendrick KM;Hanking V;Landgraf R;Wüllner U;Maier W;Hurlemann R
鼻腔内催产素对人类社会认知和行为的调节作用已经引起了前所未有的兴趣，然而，到目前为止还没有研究表明这种给药方式会增加人类大脑和血液中催产素的浓度。在这里，在接受24IU催产素(n=11)或安慰剂(n=4)的受试者中，使用血液和脑脊液(CSF)的联合采样，我们发现血浆和脑脊液中的催产素水平都显着增加。然而，催产素的血浆浓度在鼻腔给药后15 分钟达到峰值，并在75 分钟后下降，而脑脊液浓度在75 分钟后达到显著水平。此外，催产素血浆浓度与脑脊液浓度之间无相关性(r=-lt；0.10)。总之，这些数据为鼻腔给药催产素的血浆和脑脊液动力学提供了重要的见解。
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin.