Daily Patterns of Marijuana and Alcohol Co-Use Among Individuals with Alcohol and Cannabis Use Disorders
Daily Patterns of Marijuana and Alcohol Co-Use Among Individuals with Alcohol and Cannabis Use Disorders
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DOI：
10.1111/acer.13639
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发表时间：
2018-06-01
影响因子：
3.2
通讯作者：
Borsari, Brian
中科院分区：
文献类型：
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作者：
Metrik, Jane;Gunn, Rachel L.;Borsari, Brian
背景本研究的目的是检查大麻和酒精使用之间的日常联系，以及大麻使用障碍（CUD）和/或酒精使用障碍（AUD）诊断功能的联系差异程度。在过去180天内使用大麻和酒精（22，860次观察）。参与者报告了40%的大麻使用日，28%的饮酒日，37%符合DSM-5标准的CUD，40%符合AUD，15%符合两者。在给定的一天使用大麻被用来预测3级性别调整饮酒变量（重：5（男性）/4（女性）饮料;中度：1至4/3饮料;或无：0饮料）。将分类4级变量（无诊断、AUD、CUD或两者）作为大麻与酒精关系的调节因素进行了测试。结果多水平建模分析表明，与适度饮酒相比，参与者更有可能大量饮酒（OR=2.34）和适度饮酒（OR=1.61）在大麻使用日相对于不使用日。在大麻的使用天，那些与AUD和AUD+CUD更有可能大量饮酒（OR=1.91; OR=2.51，分别），但那些与CUD不太可能大量饮酒（OR=0.32）相比，适度，任何与适度饮酒之间的相互作用models.ConclusionsHeavy饮酒发生在大麻也被使用的日子。这种关联在诊断为AUD和CUD以及单独AUD的个体中特别明显，但在仅CUD的个体中不明显。研究结果表明，酒精干预可能需要专门解决大麻使用作为大量饮酒和AUD的风险因素。
BackgroundThe study aims were to examine daily associations between marijuana and alcohol use and the extent to which the association differs as a function of cannabis use disorder (CUD) and/or alcohol use disorder (AUD) diagnosis.MethodsTimeline Followback interview data was collected in a study of veterans (N=127) recruited from a Veterans Affairs hospital who reported at least 1day of co-use of marijuana and alcohol in the past 180days (22,860 observations). Participants reported 40% marijuana use days, 28% drinking days, with 37% meeting DSM-5 criteria for CUD, 40% for AUD, and 15% for both. Use of marijuana on a given day was used to predict a 3-level gender-adjusted drinking variable (heavy: 5 (men)/4 (women) drinks; moderate: 1 to 4/3 drinks; or none: 0 drinks). A categorical 4-level variable (no diagnosis, AUD, CUD, or both) was tested as a moderator of the marijuana-alcohol relationship.ResultsMultilevel modeling analyses demonstrated that participants were more likely to drink heavily compared to moderately (OR=2.34) and moderately compared to not drinking (OR=1.61) on marijuana use days relative to nonuse days. On marijuana use days, those with AUD and those with AUD+CUD were more likely to drink heavily (OR=1.91; OR=2.51, respectively), but those with CUD were less likely to drink heavily (OR=0.32) compared to moderately, nonsignificant differences between any versus moderate drinking in interaction models.ConclusionsHeavy drinking occurs on days when marijuana is also used. This association is particularly evident in individuals diagnosed with both AUD and CUD and AUDs alone but not in those with only CUDs. Findings suggest that alcohol interventions may need to specifically address marijuana use as a risk factor for heavy drinking and AUD.