The mouse Hoxc11 gene:: genomic structure and expression pattern
The mouse Hoxc11 gene:: genomic structure and expression pattern
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DOI：
10.1016/s0925-4773(97)00182-2
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发表时间：
1998-01-01
影响因子：
2.6
通讯作者：
Capecchi, MR
中科院分区：
文献类型：
--
作者：
Hostikka, SL;Capecchi, MR
小鼠和人类的 Hox 复合体由 4 个连锁群 (A-D) 中的 39 个基因组成。尽管大多数这些基因的结构和表达模式已被报道，但 Hox C 连锁群的 5' 成员仅得到部分表征。在此，我们报告了小鼠 Hoxc11 基因的初级结构和基因组结构及其表达模式。 Hoxc11 基因编码一个 304 个氨基酸的蛋白质，该蛋白质是从两个外显子衍生的 2.2 kb 转录物翻译而来的。 Hoxc11 mRNA 被发现于妊娠 9.5 天开始发育的胚胎的最后区域。在后神经管、背根神经节、前椎骨和后肢中检测到表达。后肾间质中也有表达，后肾间质在发育后期，仅限于发育中肾脏的皮质区域。在发育中的生殖器中，首先在产生尿道、阴道和前列腺的后泌尿生殖窦中观察到显着的表达。随后，在副中肾管和中肾管以及生殖结节中观察到表达。在后肢中，Hoxc11 表达见于形成股骨和腓骨区域后方的间质中，但不会向前延伸至形成胫骨的区域或跗骨远端。 (C) 1998 爱思唯尔科学爱尔兰有限公司
The mouse and human Hox complex consists of 39 genes in four linkage groups (A-D). Although the structure and expression patterns of most of these genes have been reported, the 5' members of the Hox C linkage group have been only partially characterized. Herein we report the primary and genomic structure of the mouse Hoxc11 gene as well as its expression pattern. The Hoxc11 gene encodes a 304 amino acid protein which is translated from a 2.2 kb transcript, derived from two exons. Hoxc11 mRNA is found in the most posterior region of the developing embryo commencing at 9.5 days of gestation. Expression is detected in the posterior neural tube, dorsal root ganglia, prevertebrae and hindlimbs. Expression is also found in metanephric mesenchyme which, later in development, becomes restricted to the cortical region of the developing kidney. In the developing genitalia, prominent expression is first observed in the posterior urogenital sinus that gives rise to the urethra, vagina and prostate. Later, expression is seen in paramesonephric and mesonephric ducts and in the genital tubercle. In the hindlimbs, Hoxc11 expression is seen in the mesenchyme posterior to the region forming the femur and fibula, but does not extend anteriorly to the region giving rise to the tibia or distally to the tarsal bones. (C) 1998 Elsevier Science Ireland Ltd.