Male-female differences in the relationship between obesity and lipids/lipoproteins.
Male-female differences in the relationship between obesity and lipids/lipoproteins.
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发表时间：
1996-08
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通讯作者：
C. Margolis;D. Sprecher;L. Simbartl;B. Campaigne
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作者：
C. Margolis;D. Sprecher;L. Simbartl;B. Campaigne
目的研究性别对肥胖指标与血脂/脂蛋白之间关系的影响。设计成年男性和女性的横断面、配对观察性研究。受试者来自辛辛那提，俄亥俄州的225对配偶（年龄范围，28-66岁;平均值+/- SD（年），44.0 +/- 6.7（男性），42.1 +/- 5.9（女性）。测量体重测量，脂质，脂蛋白，载脂蛋白，体力活动水平，吸烟和饮食变量。结果女性的胆固醇（r = 0.24vs0.10）、低密度脂蛋白胆固醇（r = 0.27vs0.12）、甘油三酯（r = 0.48vs0.23）和胆固醇/高密度脂蛋白胆固醇比值（r = 0.47vs0.28）与体重指数（BMI）的相关性均强于男性。利用统计回归模型，其中包括潜在的混杂环境因素，BMI和腰臀比都贡献了显着的信息来描述女性的胆固醇，HDL-C，TG和胆固醇/HDL-C值，而腰臀比单独提供这些脂质/脂蛋白在男性的信息。结论女性BMI与血脂/脂蛋白之间的相关性似乎比男性更强。在女性中，与男性相反，BMI和WHR，在临床环境中容易获得的措施，在解释这些脂质/脂蛋白水平时提供单独的独立信息。
OBJECTIVE To examine the effect of gender on the relationship between obesity measures and lipids/lipoproteins. DESIGN Cross-sectional, matched observational study of adult men and women. SUBJECTS 225 spousal pairs from Cincinnati, Ohio (age range, 28-66 years; mean +/- SD (yr), 44.0 +/- 6.7 (men), 42.1 +/- 5.9 (women). MEASUREMENTS Body mass measures, lipids, lipoproteins, apolipoproteins, physical activity levels, cigarette use and dietary variables. RESULTS Correlations between the lipids/lipoproteins and body mass index (BMI) were stronger in women than in men for cholesterol (r = 0.24 vs 0.10), LDL-c (r = 0.27 vs 0.12), triglycerides (TG) (r = 0.48 vs 0.23) and the ratio cholesterol/HDL-c (r = 0.47 vs 0.28). Utilizing statistical regression models which included potentially confounding environmental factors, BMI and WHR both contributed significant information to describe cholesterol, HDL-c, TG and cholesterol/HDL-c values in women, whereas WHR alone provided information for these lipids/lipoproteins in men. CONCLUSION The association between BMI and lipids/lipoproteins appears to be stronger in women than in men. In women, in contrast to men, BMI and WHR, measures which are easily attainable in the clinical setting, provide separate, independent information in the explanation of these lipid/lipoprotein levels.