Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
Centrins, gatekeepers for the light-dependent translocation of transducin through the photoreceptor cell connecting cilium
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DOI：
10.1016/j.visres.2006.07.029
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发表时间：
2006-12-01
期刊：
影响因子：
1.8
通讯作者：
Wolfrum, Uwe
中科院分区：
文献类型：
--
作者：
Giessl, Andreas;Trojan, Philipp;Wolfrum, Uwe
中心体蛋白是EF-hand超家族中高度保守的Ca2+结合蛋白亚群的成员，通常与中心体相关结构相关。在视网膜中，中心体也是感光细胞睫状体的重要组成部分。中心蛋白同工异构体不同地定位于基部和连接纤毛的管腔。所有内外节之间的分子交换都是通过这条狭窄的连接纤毛进行的。Ca2+激活的中心蛋白异构体通过与β - γ亚基的相互作用与视觉异三聚体g蛋白转导蛋白结合。中心蛋白/ g蛋白复合物的Ca2+依赖性组装可能通过连接纤毛调节转导蛋白的运动。该复合物的形成代表了一种调节感觉细胞中信号蛋白易位的新机制，以及分子运输和信号转导之间的潜在联系。(c) 2006 Elsevier Ltd.版权所有。
Centrins are members of a highly conserved subgroup of the EF-hand superfamily of Ca2+-binding proteins commonly associated with centrosome-related structures. In the retina, centrins are also prominent components of the photoreceptor cell ciliary apparatus. Centrin isoforms are differentially localized at the basal body and in the lumen of the connecting cilium. All molecular exchanges between the inner and outer segments occur through this narrow connecting cilium. Ca2+-activated centrin isoforms bind to the visual heterotrimeric G-protein transducin via an interaction with the beta gamma-subunit. Ca2+-dependent assemblies of centrin/G-protein complexes may regulate the transducin movement through the connecting cilium. Formation of this complex represents a novel mechanism in regulation of translocation of signaling proteins in sensory cells, as well as a potential link between molecular trafficking and signal transduction in general. (c) 2006 Elsevier Ltd. All rights reserved.