Antioxidant defense and trace element imbalance in patients with postradiation syndrome - First report on phase I studies
Antioxidant defense and trace element imbalance in patients with postradiation syndrome - First report on phase I studies
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DOI：
10.1385/bter:77:1:1
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发表时间：
2000-10-01
影响因子：
3.9
通讯作者：
Rainsford, KD
中科院分区：
文献类型：
--
作者：
Kumerova, AO;Lece, AG;Rainsford, KD
6000多名拉脱维亚居民参与了切尔诺贝利的恢复工作。他们是暴露于大量电离辐射（0.01-0.5 Gy）的健康男性。现在，这些康复工作者患上了“放射后综合症”：头晕、记忆力差、头痛、局部疼痛等等。“辐照后综合征”的生化机制尚未完全确立。在这个第一阶段的研究中，我们研究了暴露于辐射如何影响抗氧化防御和血液中微量元素浓度的恢复工人。研究了35例放射后综合征患者（男性，年龄33-50岁）和15例年龄相近的健康男性作为对照，对血浆化学发光、抗氧化酶活性、铜蓝蛋白浓度和血硒、锌、铜浓度的影响。结果显示，检查患者血浆化学发光明显增加（3.5 ~ 5.5倍），红细胞过氧化氢酶活性显著升高，血浆谷胱甘肽过氧化物酶活性显著降低。这些患者的锌、铜浓度明显升高，硒浓度明显降低。我们得出的结论是，暴露于电离辐射的患者血液抗氧化防御能力下降，与明显的硒缺乏和锌、铜失衡有关。
More than 6000 residents of Latvia were involved in recovery work in Chemobyl. They were healthy men exposed to substantial ionizing radiation (0.01-0.5 Gy). Now, these recovery workers suffer from "postradiation syndrome": dizziness and poor memory, headache, local pains, and so forth. The biochemical mechanism of "postradiation syndrome" has not been completely established. In this Phase I study, we have investigated how exposure to radiation impacts antioxidative defense and trace element concentrations in the blood of recovery workers. Thirty-five patients with postradiation syndrome (men, age range 33-50 yr) and 15 healthy men similar in age as control subjects were studied for the effects on plasma chemiluminescence, the activity of antioxidant enzymes, and the concentration of ceruloplasmin and concentrations of selenium (Se), zinc (Zn), and copper (Cu) in blood. The results revealed that plasma chemiluminescence was significantly increased (3.5-fold to 5.5-fold), the activity of catalase in erythrocytes was significantly elevated, and the activity of glutathione peroxidase in plasma was significantly reduced in examined patients. Concentrations of Zn and Cu were significantly higher and the concentration of Se was lower in these patients. We conclude that the patients exposed to ionizing radiation have diminished blood antioxidant defense associated with pronounced Se deficiency and imbalance of Zn and Cu.