Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.
Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily.
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核上核中鲁棒性和弹性的基础：单个神经元在每天循环的电路中形成节点。
DOI：
10.1177/0748730409344800
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发表时间：
2009-10
影响因子：
3.5
通讯作者：
Silver R
中科院分区：
文献类型：
--
作者：
Butler MP;Silver R
SCN的蜂窝元件如何彼此同步还没有很好地理解。我们探索在细胞、组织和整个动物水平上表现的昼夜节律振荡，以更好地理解SCN内的同步性和细胞核的主时钟功能。在每个分析水平，对操作环境变化的响应（鲁棒性），以及对系统组件的后续损坏（弹性），提供了对SCN编排昼夜节律定时的机制的深入了解。组织水平的节律性揭示了与有序的时空日常活动模式相关的回路，这是无法从其细胞成分中预测的。具体而言，在稳定状态下，一些SCN区域在时钟基因表达中表达低振幅或不可检测的节律，而其他区域产生高振幅振荡。在SCN内，时钟基因表达遵循空间有序的重复激活和失活模式。这种激活模式是可塑的，有助于对外部和内部条件变化的反应。就像细胞水平的日常节律依赖于生物钟基因的顺序表达和相互作用一样，SCN组织水平的节律也依赖于局部节点的顺序激活。我们假设单个神经元被组织成节点，这些节点在每天重复的循环中在SCN的体积上顺序激活。我们进一步提出，鲁棒性表示在SCN的能力，以维持在广泛的内部和外部条件的节律性，这反映了可塑性的基础节点和电路。恢复力表现为SCN细胞在行为水平上振荡和维持活动相关节律的能力。重要的是，起搏器功能的其他方面仍有待研究。
How the cellular elements of the SCN are synchronized to each other is not well understood. We explore circadian oscillations manifest at the level of the cell, the tissue, and the whole animal to better understand intra-SCN synchrony and master clock function of the nucleus. At each level of analysis, responses to variations in operating environment (robustness), and following damage to components of the system (resilience), provide insight into the mechanisms whereby the SCN orchestrates circadian timing. Tissue level rhythmicity reveals circuits associated with an orderly spatiotemporal daily pattern of activity that is not predictable from their cellular elements. Specifically, in stable state, some SCN regions express low amplitude or undetectable rhythms in clock gene expression while others produce high amplitude oscillations. Within the SCN, clock gene expression follows a spatially ordered, repeated pattern of activation and inactivation. This pattern of activation is plastic and subserves responses to changes in external and internal conditions. Just as daily rhythms at the cellular level depend on sequential expression and interaction of clock genes, so too do rhythms at the SCN tissue level depend on sequential activation of local nodes. We hypothesize that individual neurons are organized into nodes that are themselves sequentially activated across the volume of the SCN in a cycle that repeats on a daily basis. We further propose that robustness is expressed in the ability of the SCN to sustain rhythmicity over a wide range of internal and external conditions, and that this reflects plasticity of the underlying nodes and circuits. Resilience is expressed in the ability of SCN cells to oscillate and to sustain activity-related rhythms at the behavioral level. Importantly, other aspects of pacemaker function remain to be examined.
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影响因子：
64.8
作者：
Cheng, MY;Bullock, CM;Zhou, QY
通讯作者：
Zhou, QY
影响因子：
3.5
作者：
Brown, T. M.;Piggins, H. D.
通讯作者：
Piggins, H. D.
影响因子：
5.3
作者：
Choi, Hee Joo;Lee, C. Justin;Kim, Yang In
通讯作者：
Kim, Yang In
影响因子：
5.3
作者：
Gamble, Karen L.;Allen, Gregg C.;McMahon, Douglas G.
通讯作者：
McMahon, Douglas G.
影响因子：
3.4
作者：
Gonze, D;Bernard, S;Herzel, H
通讯作者：
Herzel, H