Serum sphingolipid profile in asthma
Serum sphingolipid profile in asthma
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DOI：
10.1002/jlb.3ma1120-719r
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发表时间：
2021-02-18
影响因子：
5.5
通讯作者：
Chang, Chun
中科院分区：
文献类型：
--
作者：
Guo, Chenglin;Sun, Lina;Chang, Chun
鞘磷脂代谢是一个重要的细胞过程，在哮喘中起着关键作用。然而，鞘磷脂在哮喘及其亚型发病机制中的作用尚不清楚。本研究旨在确定鞘脂在哮喘及其亚型中的作用。收集51例哮喘患者和9例健康体检者的临床资料，采用液-质联用靶向代谢组学方法分析血清鞘磷脂水平。结果表明，哮喘患者的鞘磷脂(SM)水平包括SM34：2、SM38：1和SM40：1均显著低于健康对照组。此外，血液非嗜酸性哮喘(BNEA)组血清SM水平明显低于血嗜酸性哮喘组(P<0.05)。早发组与晚发组的血清SM水平变化趋势相似。相关分析显示，SM 40：1与痰IL-17A呈负相关(r=-0.621，P=0.042)。本研究提示丹参可能是哮喘的保护因子，并参与哮喘的发病机制，尤其是bNEA。SM可能是哮喘的潜在生物标志物和治疗靶点。
Sphingolipids metabolism is an important cell process and plays critical roles in asthma. However, the involvement of sphingolipids in the pathogenesis of asthma and its subtypes is unknown. The present study aimed to determine the role of sphingolipids in asthma and its subtypes. Clinical data from 51 asthma patients and 9 healthy individuals were collected and serum samples were performed to analyze the levels of serum sphingolipids by liquid chromatography-mass spectrometry-based targeted metabolomics. Results showed that the levels of sphingomyelin (SM) including SM34:2, SM38:1, and SM40:1 were significantly decreased in asthmatic patients compared to healthy controls. Moreover, serum SM levels were obviously decreased in the blood noneosinophilic asthma (bNEA) group compared with blood eosinophilic asthma group. Similar tendencies of serum SM level changes were observed in the early-onset group compared with late-onset group. Correlation analysis revealed that SM 40:1 was negatively related to sputum IL-17A (r = -0.621, P = 0.042). The present study presented that the SM may be a protective factor of asthma and contributes to the mechanism of asthma, especially bNEA. SM may be a potential biomarker and therapeutic target in asthma.