Proteome-Scale Analysis of Protein S-Acylation Comes of Age.
Proteome-Scale Analysis of Protein S-Acylation Comes of Age.
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DOI：
10.1021/acs.jproteome.0c00409
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发表时间：
2021-01-01
影响因子：
4.4
通讯作者：
Yang W
中科院分区：
文献类型：
--
作者：
Wang Y;Yang W
蛋白质S-酰化（通常称为棕榈酰化）是一种广泛存在的可逆脂质修饰，其在调节蛋白质定位、活性、稳定性和复合物形成中起关键作用。蛋白质S-酰化的失调导致许多疾病，如癌症和神经退行性疾病。在过去的十年中，蛋白质组学研究取得了实质性进展，这大大提高了我们对S-酰化生物学的理解。本文综述了S-酰化蛋白质或肽的富集技术，对8个不同水平的蛋白质S-酰化的蛋白质组学研究进行了评述，并提出了S-酰化蛋白质组学领域面临的主要挑战。总之，蛋白质组规模的蛋白质S-酰化分析已经成熟，并将在发现新的疾病机制，生物标志物和治疗靶点方面发挥越来越重要的作用。
Protein S-acylation (commonly known as palmitoylation) is a widespread reversible lipid modification, which plays critical roles in regulating protein localization, activity, stability, and complex formation. The deregulation of protein S-acylation contributes to many diseases such as cancer and neurodegenerative disorders. The past decade has witnessed substantial progress in proteomic analysis of protein S-acylation, which significantly advanced our understanding of S-acylation biology. In this review, we summarized the techniques for the enrichment of S-acylated proteins or peptides, critically reviewed proteomic studies of protein S-acylation at eight different levels, and proposed major challenges for the S-acylproteomics field. In summary, proteome-scale analysis of protein S-acylation comes of age and will play increasingly important roles in discovering new disease mechanisms, biomarkers, and therapeutic targets.
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