Glucose metabolism in small subcortical structures in Parkinson's disease
Glucose metabolism in small subcortical structures in Parkinson's disease
复制标题
DOI：
10.1111/j.1600-0404.2011.01556.x
复制
发表时间：
2012-05-01
影响因子：
3.5
通讯作者：
Gjedde, Albert
中科院分区：
文献类型：
--
作者：
Borghammer, Per;Hansen, Soren B.;Gjedde, Albert
目的帕金森病（PD）实验动物模型的证据表明，在离散的，非常小的基底神经节结构的代谢紊乱的特征模式。这些结构通常太小而不允许通过常规正电子发射断层摄影（PET）相机进行有效调查。然而，高分辨率研究断层扫描仪（HRRT）PET系统的分辨率为2 mm，足以研究重要结构，如苍白球和丘脑亚核。材料和方法：我们使用高分辨放射治疗，对21名帕金森病患者和11名年龄匹配的对照者进行[F-18]-氟脱氧葡萄糖（FDG）扫描。我们采用了三种类型的标准化：白色物质，全球平均值和数据驱动的标准化。我们对皮质下灰质结构进行了感兴趣体积分析。进行基于体素的比较以研究皮质代谢减退的程度。结果-最显着水平的相对皮质下高代谢检测外苍白球（GPe），无论正常化策略。高代谢也建议在内部苍白球，丘脑亚核，和壳核。广泛的皮质代谢减退的模式非常类似于以前报告的模式与PD患者。结论：帕金森病皮质下高代谢的存在和程度取决于正常化的类型。然而，目前的研究结果表明，PD，除了广泛的皮质低代谢，可能是真正的高代谢的GPe的特点。动物2-脱氧葡萄糖放射自显影文献预测了这一发现，其中在GPe中也最强烈地检测到高幅度的高代谢。
Objectives Evidence from experimental animal models of Parkinsons disease (PD) suggests a characteristic pattern of metabolic perturbation in discrete, very small basal ganglia structures. These structures are generally too small to allow valid investigation by conventional positron emission tomography (PET) cameras. However, the high-resolution research tomograph (HRRT) PET system has a resolution of 2 mm, sufficient for the investigation of important structures such as the pallidum and thalamic subnuclei. Materials and methods -Using the HRRT, we performed [F-18]-fluorodeoxyglucose (FDG) scans on 21 patients with PD and 11 age-matched controls. We employed three types of normalization: white matter, global mean, and data-driven normalization. We performed volume-of-interest analyses of small subcortical gray matter structures. Voxel-based comparisons were performed to investigate the extent of cortical hypometabolism. Results -The most significant level of relative subcortical hypermetabolism was detected in the external pallidum (GPe), irrespective of normalization strategy. Hypermetabolism was suggested also in the internal pallidum, thalamic subnuclei, and the putamen. Widespread cortical hypometabolism was seen in a pattern very similar to previously reported patterns in patients with PD. Conclusion -The presence and extent of subcortical hypermetabolism in PD is dependent on type of normalization. However, the present findings suggest that PD, in addition to widespread cortical hypometabolism, is probably characterized by true hypermetabolism in the GPe. This finding was predicted by the animal 2-deoxyglucose autoradiography literature, in which high-magnitude hypermetabolism was also most robustly detected in the GPe.