Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer.
Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer.
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DOI：
10.3389/fonc.2015.00207
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发表时间：
2015
影响因子：
4.7
通讯作者：
Wikman H
中科院分区：
文献类型：
--
作者：
Hanssen A;Loges S;Pantel K;Wikman H
肺癌是与癌症相关的死亡的最常见原因，通常在疾病诊断之前转移。循环肿瘤细胞(CTCs)广泛存在于多种不同类型的上皮性肿瘤中，在临床预后和治疗干预方面具有重要意义。在这里，我们提出并讨论了非小细胞肺癌(NSCLC)中上皮细胞黏附分子依赖和非独立捕获的CTC，以及CTC检测和表征的临床意义。采集血液样本并分析CTC作为“液体活组织检查”可能比肺肿瘤或转移的活组织检查具有更小的侵入性。此外，顺序采血可以研究治疗过程中肿瘤细胞的动态变化，特别是耐药肿瘤细胞克隆的发展。
Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as “liquid biopsy” might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.