Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis.
Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis.
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长期非编码RNA：神经胶质瘤发病机理的主要参与者。
DOI：
10.3390/cancers7030843
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发表时间：
2015-07-29
期刊：
影响因子：
5.2
通讯作者：
Leung GK
中科院分区：
文献类型：
--
作者：
Kiang KM;Zhang XQ;Leung GK
长非编码RNAs(Long Non-Coding RNAs，LncRNAs)是一类没有蛋白质编码功能的新型RNAs，但LncRNAs与其他分子之间的相互作用在不同的环境中发挥着重要的基因调控功能。鉴于其在大脑中的相对高表达，lncRNAs现在被认为在正常的大脑发育以及包括胶质瘤形成在内的各种疾病过程中发挥重要作用。有趣的是，某些lncRNAs与胶质瘤的发生、分化、进展、复发和干细胞性特征密切相关，因此可用于亚型分类、诊断和预后。在脑胶质瘤的治疗中，lncRNAs也可能作为潜在的治疗靶点和一种新的生物标志物。在这篇文章中，将简要讨论lncRNAs的功能方面，特别是在中枢神经系统(CNS)内，然后重点介绍lncRNAs在神经胶质瘤发展过程中的重要作用。此外，还将讨论与胶质瘤发生相关的关键LncRNA成员及其可能的机制途径。
Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.