Promising Gene Therapeutics for Salivary Gland Radiotoxicity.
Promising Gene Therapeutics for Salivary Gland Radiotoxicity.
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DOI：
10.3934/medsci.2016.4.329
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发表时间：
2016
影响因子：
0.7
通讯作者：
Sunavala-Dossabhoy G
中科院分区：
文献类型：
--
作者：
Nair RP;Sunavala-Dossabhoy G
全世界每年诊断出超过50万例头颈癌新病例，其中约75%仅接受放射治疗或与其他癌症治疗联合治疗。由于不可避免的对正常组织的照射，大多数接受放射治疗的患者会产生显著的口腔脱靶效应。位于治疗区域内的唾液腺通常会受到不可修复的损伤，功能下降表现为口干或口干。唾液腺再生失去的腺泡细胞的能力有限，这使得放射诱导的功能丧失成为一个慢性问题，其影响患者的生活质量，远远超过放射治疗的完成。辐射后唾液生产的恢复一直是一个艰巨的挑战，这篇综述提供了一个有前途的基因治疗的概述，无论是提高腺体的能力，生存辐射损伤，或替代，恢复辐射后的流体流动。每种方法的显着特点和缺点进行了讨论。
More than 0.5 million new cases of head and neck cancer are diagnosed worldwide each year, and approximately 75% of them are treated with radiation alone or in combination with other cancer treatments. A majority of patients treated with radiotherapy develop significant oral off-target effects because of the unavoidable irradiation of normal tissues. Salivary glands that lie within treatment fields are often irreparably damaged and a decline in function manifests as dry mouth or xerostomia. Limited ability of the salivary glands to regenerate lost acinar cells makes radiation-induced loss of function a chronic problem that affects the quality of life of the patients well beyond the completion of radiotherapy. The restoration of saliva production after irradiation has been a daunting challenge, and this review provides an overview of promising gene therapeutics that either improve the gland’s ability to survive radiation insult, or alternately, restore fluid flow after radiation. The salient features and shortcomings of each approach are discussed.