COGNITIVE AND MOTOR DEFICITS IN THE PERFORMANCE OF AN OBJECT RETRIEVAL TASK WITH A BARRIER-DETOUR IN MONKEYS (CERCOPITHECUS-AETHIOPS-SABAEUS) TREATED WITH MPTP - LONG-TERM PERFORMANCE AND EFFECT OF TRANSPARENCY OF THE BARRIER
COGNITIVE AND MOTOR DEFICITS IN THE PERFORMANCE OF AN OBJECT RETRIEVAL TASK WITH A BARRIER-DETOUR IN MONKEYS (CERCOPITHECUS-AETHIOPS-SABAEUS) TREATED WITH MPTP - LONG-TERM PERFORMANCE AND EFFECT OF TRANSPARENCY OF THE BARRIER
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DOI：
10.1037/0735-7044.104.4.564
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发表时间：
1990-08-01
影响因子：
1.9
通讯作者：
REDMOND, DE
中科院分区：
文献类型：
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作者：
TAYLOR, JR;ROTH, RH;REDMOND, DE
为了评估1-甲基-4-苯基- 1,2,3,6 -四氢吡啶（MPTP）引起的神经缺陷的稳定性，研究了猴子在物体检索（绕道）任务中的表现。这项任务需要从一个透明的盒子里取出一片香蕉片，盒子的一侧打开，并固定在笼子前面的托盘上。打开的一面的方向，在托盘上的位置，以及香蕉在盒子里的位置被操纵来改变试验的难度。6只非洲绿猴（Cercopithecus aethiops sabaeus）被MPTP （1.5-1.6 mg/kg， 4-5天累积剂量）处理，并与5只盐水处理的对照猴子进行比较。mptp治疗的猴子没有严重的神经功能缺陷，但在治疗后8-12个月的物体检索任务中确实存在运动和认知缺陷（JR Taylor, Elsworth, Roth, Sladek, & Redmond, in press）。在学习后的3个月里，对任务的表现进行了测试。mptp治疗的受试者到达屏障（透明侧）的次数明显多于对照组，并且在第一次到达时获得奖励的成功率低于对照组。尽管与对照组相比，他们花了更长的时间来开始接触，并且有更多的运动问题，但他们最终取回奖励的可能性与对照组一样高。这些缺陷在整个测试过程中保持稳定。在一些试验中，随机使用了一个不透明但其他方面完全相同的盒子。在使用不透明盒子的实验中，mptp治疗的受试者减少了障碍达到控制水平，而与使用透明盒子的实验相比，运动问题增加了。这项任务可以检测出与帕金森病相似的细微表现缺陷。
To assess the stability of neural deficits produced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), the performance of monkeys on an object retrieval (detour) task was studied. The task required retrieval of a banana slice from a transparent box open on one side and fastened to a tray in front of the cage. The orientation of the open side, position on the tray, and position of the banana in the box were manipulated to vary the difficulty of the trials. Six African green monkeys (Cercopithecus aethiops sabaeus) were treated with MPTP (1.5–1.6 mg/kg cumulative doses over 4–5 days) and compared with 5 saline-treated control monkeys. The MPTP-treated monkeys had no gross neurological deficits but did have motor and cognitive deficits during acquisition of the object retrieval task 8–12 months after treatment (JR Taylor, Elsworth, Roth, Sladek, & Redmond, in press). Performance on the task was examined for 3 months after it had been learned. The MPTP-treated subjects reached at the barrier (transparent side) significantly more than controls and were less successful at retrieving the reward on the 1st reach than controls. Although they took longer to initiate the reach and had more motor problems than controls, they were as likely as controls to retrieve the reward in the end. These deficits remained stable throughout testing. An opaque but otherwise identical box was used randomly on some trials. MPTP-treated subjects decreased barrier reaches to control levels on trials in which the opaque box was used, whereas motor problems increased compared with trials in which the transparent box was used. The task can detect subtle performance deficits similar to those found in Parkinson's disease.