The bacteria of periodontal diseases.
The bacteria of periodontal diseases.
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DOI：
10.1111/j.1600-0757.1994.tb00019.x
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发表时间：
1994-06-01
影响因子：
18.6
通讯作者：
Moore, L V
中科院分区：
文献类型：
--
作者：
Moore, W E;Moore, L V
从婴儿期到死亡，人们几乎把手指放在周围的所有东西上，包括食物和嘴里。大多数能够在口腔或胃肠道中生存的微生物都有机会在那里定居。通过直接或间接接触，这些细菌与后代和其他人共享。但是，尽管人与人之间频繁接触和潜在的细菌种类转移 (34)，每个人都倾向于维持自己独特的牙周、皮肤和肠道菌群 (11,26,28)。尽管不同人体内存在的细菌种类存在重叠，但个体倾向于保留更多的一组或另一组细菌。即使在抗生素治疗后，个体也往往会恢复自己独特的菌群。目前尚不清楚菌群组成的个体差异主要是由遗传还是环境影响控制。 Moore等人(25)发现，生活在同一家庭的双胞胎儿童的牙周菌群明显比同龄无亲缘儿童的牙周菌群更加相似，这表明环境和/或遗传可以影响菌群的组成。在那项研究中，同卵双胞胎的牙周菌群比异卵双胞胎的牙周菌群更相似，这表明菌群组成存在一定的遗传控制（25）。某些牙周物种的发生在不同人类种族的成员中存在显着差异（39），这也可能表明遗传对菌群组成的影响。免疫反应因人而异，这可能受到遗传或环境控制（通过之前的接触史），但这表明任何特定的细菌种类对所有人来说可能并不具有同等的重要性。
From infancy until death, people put their fingers on nearly everything around them, including their food, and in their mouths. Most microbes that can survive in the mouth or gastrointestinal tract continually have the opportunity to establish residence there. Through direct or indirect contact, these bacteria are shared with offspring and with other people. But in spite of frequent contact and potential transfer of bacterial species between people (34), each person tends to maintain his or her own unique periodontal, skin and intestinal floras (11, 26, 28). Although there is an overlap among the kinds of bacteria present in different people, individuals tend to maintain more of one or another group of species. Even after antibiotic therapy, individuals tend to regain their own unique flora. It is not clear whether the individual differences in flora composition are controlled primarily by genetic or by environmental influences. Moore et al.(25) have found that the periodontal floras of twin children living in the same households were significantly more similar than those of unrelated children of the same ages, indicating that environment and/or genetics can influence the composition of the flora. In that study, the periodontal floras of identical twins were more similar than those of fraternal twins, which indicates that there is some genetic control of flora composition (25). The occurrence of some periodontal species is significantly different among members of different human races (39), which also may indicate a genetic influence on flora composition. Immune response varies among individuals, and this may be under either genetic or environmental control through history of previous exposure, but it indicates that any given bacterial species may not be of equal significance to all people.