Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature.
Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature.
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DOI：
10.1002/pbc.25574
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发表时间：
2015-09
影响因子：
3.2
通讯作者：
Panepinto JA
中科院分区：
文献类型：
--
作者：
Brandow AM;Farley RA;Panepinto JA
最近发现了镰状细胞病（SCD）疼痛的神经生物学新见解。我们系统地回顾了原始研究的文献，这些研究检查了SCD疼痛的生物学和/或解决了SCD神经性疼痛的评估和治疗。本文回顾了符合纳入标准的15篇文章，提供了流行病学、基础和临床数据，支持中枢和/或周围神经系统异常可能导致镰状细胞性疼痛。继续对疼痛神经生物学的基础和临床研究是必要的，将这些发现转化为评估和治疗神经性疼痛的新方法，并减少患者的痛苦。
Novel insights into the neurobiology of sickle cell disease (SCD) pain have recently been discovered. We systematically reviewed the literature focusing on original research that examined the biology of pain in SCD and/or addressed assessment or treatment of neuropathic pain in SCD. This review of 15 articles that met inclusion criteria provides epidemiological, basic and clinical data that support central and/or peripheral nervous system abnormalities likely contribute to sickle cell pain. Continued basic and clinical investigation into pain neurobiology is imperative to translate these discoveries into novel ways to assess and treat neuropathic pain and decrease patient suffering.