The translocator protein (TSPO): A novel target for cancer chemotherapy
The translocator protein (TSPO): A novel target for cancer chemotherapy
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DOI：
10.1016/j.biocel.2013.03.004
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发表时间：
2013-07-01
影响因子：
4
通讯作者：
Rendina, Louis M.
中科院分区：
文献类型：
--
作者：
Austin, Christopher J. D.;Kahlert, Jan;Rendina, Louis M.
转运蛋白（TSPO）是一种18 kDa的跨膜蛋白，主要存在于线粒体外膜中，形成线粒体通透性转换孔（MFTP）的关键部分。TSPO上调几乎存在于所有组织中，与神经元损伤和炎症有关，使该蛋白成为疾病进展的重要生物成像标记物。最近，TSPO作为肿瘤成像和化疗的可能分子靶点引起了人们的注意。本文综述了TSPO的分子特征，并重点介绍了近年来TSPO靶向肿瘤诊断和治疗领域的研究进展。皇冠版权所有（C）2013由爱思唯尔有限公司出版。保留所有权利。
The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MFTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.