Synthesis of novel Gn-RH analogues using Ugi-4MCR
Synthesis of novel Gn-RH analogues using Ugi-4MCR
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DOI：
10.1016/j.bmcl.2008.11.111
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发表时间：
2009-02-01
影响因子：
2.7
通讯作者：
Gross, Juergen H.
中科院分区：
文献类型：
--
作者：
Arabanian, Armin;Mohammadnejad, Mahdieh;Gross, Juergen H.
本文报道了一种基于Ugi反应合成某些GnRH类似物的有效方法。N-和C-末端肽，芳香醛和异腈的四组分反应提供了衍生自曲普瑞林和戈那瑞林的新型Gn-RH类似物。使用制备型HPLC纯化所有产物，并根据MALDI-质谱数据归属结构。皇冠版权所有（C）2008由爱思唯尔有限公司出版。保留所有权利。
An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.