Chemokine-chemokine receptor pathway as a tumor therapeutic target: the significance of SDF-1CXCR4 pair
Chemokine-chemokine receptor pathway as a tumor therapeutic target: the significance of SDF-1CXCR4 pair
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DOI：
10.14748/bmr.v16.96
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发表时间：
2005-12
期刊：
影响因子：
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通讯作者：
P. Lu;Long-biao Li;Xueguang Zhang
中科院分区：
文献类型：
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作者：
P. Lu;Long-biao Li;Xueguang Zhang
趋化因子是一大类趋化细胞因子，是免疫细胞转运的主要调节因子。趋化因子基质细胞衍生因子-1(SDF-1或CXCL12)及其同源受体CXCR4(CD184)是一对重要的配体-受体，在造血、炎症、血管生成和细胞增殖等多种生物学过程中发挥重要作用。此外，越来越多的证据表明，SDF-1-CXCR4对在调节肿瘤生物学过程中起着重要作用。因此，旨在抑制SDF-1-CXCR4途径的分子策略，如小肽CXCR4特异性拮抗剂、抗CXCR4抗体和小干扰RNA，可能会阻止肿瘤的进展和转移。在这一轮的舞蹈中，我们主要关注(I)SDF-1-CXCR4信号在调节肿瘤扩散、生长和血管形成中的作用，以及(Ii)这种配体-受体对作为肿瘤新的治疗靶点的意义。《生物医学评论》2005；16：77-81。
Chemokines, a large family of chemotactic cytokines, are the major regulators of immune cell trafficking. The chemokine stromal cell-derived factor-1 (SDF-1, or CXCL12) and its cognate receptor, CXCR4 (CD184), are an important ligand-receptor pair, which play a crucial role in numerous biological processes including hematopoiesis, inflammation, angiogenesis, and cell proliferation. Moreover, accumulating evidence indicates that SDF-1-CXCR4 pair plays important roles in regulating processes essential for tumor biology. Molecular strategies aimed at inhibiting the SDF-1-CXCR4 pathway, such as small peptide CXCR4-specific antagonists, anti-CXCR4 antibodies, and small interfering RNA might therefore prevent tumor progression and metastasis. In the present Dance Round, we focus on (i) the role of the SDF-1-CXCR4 signaling in the regulation of tumor spread, growth, and vascularization, and (ii) the significance of this ligand-receptor pair as a novel therapeutic target for neoplastic disease. Biomedical Reviews 2005; 16: 77-81.