1,25-dihydroxyvitamin D-3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
1,25-dihydroxyvitamin D-3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
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DOI：
10.1073/pnas.93.15.7861
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发表时间：
1996-07-23
影响因子：
11.1
通讯作者：
DeLuca, HF
中科院分区：
文献类型：
--
作者：
Cantorna, MT;Hayes, CE;DeLuca, HF
实验性自身免疫性脑脊髓炎（EAE）是一种自身免疫性疾病，被认为是人类多发性硬化症（MS）的模型。髓鞘碱性蛋白（myelin basic protein， MBP）免疫B10.PL小鼠后，1,25-二羟基维生素D-3 [1,25-(OH)(2)D-3]可完全预防EAE。1,25-(OH)(2)D-3在出现第一次残疾症状时给药也可以阻止EAE的进展。1,25-(OH)(2)D-3的退出导致EAE的进展恢复。因此，1,25-(OH)(2)D-3的阻滞是可逆的。缺乏维生素D导致对EAE的易感性增加。因此，1,25-(OH)(2)D-3或其类似物对治疗多发性硬化症具有潜在的重要作用。
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3]. 1,25-(OH)(2)D-3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)(2)D-3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)(2)D-3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)(2)D-3 or its analogs are potentially important for treatment of MS.