An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent
An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent
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用于近红外激活 DNA 共价结合剂释放的上转换纳米颗粒/Ru(II) 聚吡啶复合物组件
DOI：
10.1039/c6ra03396b
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发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Wang, Xuesong
中科院分区：
文献类型：
--
作者：
Chen, Yumeng;Jiang, Guoyu;Wang, Xuesong
光活化抗癌化学疗法凭借其对辐射的时空控制的高选择性而与众不同。然而，短的光活化波长限制了其应用。本文中，将两亲性Ru（II）配合物cis-[Ru（bpy）2（C18 H37 CN）2]2+（bpy = 2，2 ′-bipyridine）与聚乙二醇修饰的脂质沿着包埋在油酸酯封端的镧系元素掺杂的上转换纳米颗粒（UCNPs）表面。所得的核-壳杂化系统是水可分散的，在黑暗中稳定，并且在980 nm激光照射时释放[Ru（bpy）2（H2O）2]2+的DNA共价结合剂，为开发近红外（NIR）光触发的化学治疗剂提供指导。
Photoactivated anticancer chemotherapy distinguishes itself by its high selectivity by virtue of the spatiotemporal control of irradiation. However, short photoactivation wavelengths limit its application. Herein, an amphiphilic Ru(II) complex, cis-[Ru(bpy)2(C18H37CN)2]2+ (bpy = 2,2′-bipyridine), was embedded along with a poly(ethylene glycol, PEG)-modified lipid onto the surfaces of oleate-capped lanthanide-doped upconversion nanoparticles (UCNPs). The resultant core–shell hybrid system is water-dispersible, stable in the dark, and releases a DNA covalent-binding agent of [Ru(bpy)2(H2O)2]2+ upon 980 nm laser irradiation, providing guidelines for developing near-infrared (NIR) light triggered chemotherapeutics.