Export Mechanisms and Energy Transduction in Type-III Secretion Machines.
Export Mechanisms and Energy Transduction in Type-III Secretion Machines.
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DOI：
10.1007/82_2019_166
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发表时间：
2019
影响因子：
--
通讯作者：
Thibaud T. Renault;Alina Guse;M. Erhardt
中科院分区：
文献类型：
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作者：
Thibaud T. Renault;Alina Guse;M. Erhardt
细菌纳米机器非常复杂的结构和组织最初提出了一个谜，即它们是如何以协调的方式组装的。多年来，鞭毛和进化相关注射复合物的组装过程已被破译，并显示依赖于一个保守的蛋白质分泌机器：iii型分泌系统。在本书的这一章中，我们展示了个体进化机制如何在高度通用和强大的分泌机制中合作，以输出和组装这些纳米机器的构建块。
The remarkably complex architecture and organization of bacterial nanomachines originally raised the enigma to how they are assembled in a coordinated manner. Over the years, the assembly processes of the flagellum and evolutionary-related injectisome complexes have been deciphered and were shown to rely on a conserved protein secretion machine: the type-III secretion system. In this book chapter, we demonstrate how individually evolved mechanisms cooperate in highly versatile and robust secretion machinery to export and assemble the building blocks of those nanomachines.