Inheritance of protection from osmotic stress.
Inheritance of protection from osmotic stress.
复制标题
渗透应激保护的遗传。
DOI：
10.1038/ncb3483
复制
发表时间：
2017
影响因子：
21.3
通讯作者：
Strome,Susan
中科院分区：
文献类型：
--
作者：
Kaneshiro,KiyomiR;Strome,Susan
暴露于温和的渗透胁迫的母亲蠕虫诱导后代的基因表达的变化，保护他们免受强渗透胁迫。保护的遗传现在被证明依赖于母体生殖系中胰岛素样信号的改变，这通过增加甘油生物合成中的限速酶zygpdh-2的表达来提供保护。
Exposure of mother worms to mild osmotic stress induces gene expression changes in offspring that protect them from strong osmotic stress. Inheritance of protection is now shown to depend on altered insulin-like signalling in the maternal germline, which confers protection through increased expression of zygoticgpdh-2, a rate-limiting enzyme in glycerol biosynthesis.