Visualizing sexual dimorphism in the brain
Visualizing sexual dimorphism in the brain
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DOI：
10.1016/j.neuron.2004.07.008
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发表时间：
2004-08-05
期刊：
影响因子：
16.2
通讯作者：
Axel, R
中科院分区：
文献类型：
--
作者：
Shah, NM;Pisapia, DJ;Axel, R
性别二态性行为可能涉及表达雄激素受体（AR）的神经通路。我们对 AR 基因座进行了基因改造，以可视化表达 AR 的神经元群体的二态性。对 AR 阳性神经元的分析揭示了下丘脑视前区和终纹床核中已知的二态性，以及基底前脑中新的二态性岛，其清晰度不受大量 AR 阴性神经元的影响。这种遗传方法可以使 AR 阳性神经元的二态性亚群及其投影可视化，并最终可能允许神经回路和特定二态性行为之间的关联。
Sexually dimorphic behaviors are likely to involve neural pathways that express the androgen receptor (AR). We have genetically modified the AR locus to visualize dimorphisms in neuronal populations that express AR. Analysis of AR-positive neurons reveals both known dimorphisms in the preoptic area of the hypothalamus and the bed nucleus of the stria terminalis as well as novel dimorphic islands in the basal forebrain with a clarity unencumbered by the vast population of AR-negative neurons. This genetic approach allows the visualization of dimorphic subpopulations of AR-positive neurons along with their projections and may ultimately permit an association between neural circuits and specific dimorphic behaviors.