Cell biology. Does Notch take the sweet road to success?
Cell biology. Does Notch take the sweet road to success?
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细胞生物学。
DOI：
10.1126/science.1110533
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Lowe,JohnB
中科院分区：
文献类型：
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作者：
Lowe,JohnB
为什么了解这些信号通路如此重要？植物激素是植物发育的核心，在植物发育的各个方面很可能都与植物激素无关。理解植物激素的发育作用是复杂的，因为每种植物激素控制着如此多的反应。此外，单一反应受多种荷尔蒙控制，这些荷尔蒙可以相互对抗，也可以协同作用。到目前为止，不同植物激素的信号通路似乎大多是相互独立的。这表明，许多不同信号的整合可能发生在更下游的基因调控水平上。事实上，BR和生长素在控制幼苗生长方面的这种整合最近已经被证明(7)，尽管大量的基因似乎是由BR或生长素独立调节的(8)。此外，GA和生长素对生长的调节至少部分是由Della蛋白的活性整合的，Della蛋白是假定的转录调节因子(9)。确定由每种激素控制的关键转录因子，以及它们之间如何相互作用，以及它们与目标基因的相互作用，对于理解植物激素如何协调植物发育至关重要。何氏等人。和Yen等人。研究是朝着这个方向迈出的重要一步。
Why is it so important to understand these signaling pathways? Phytohormones are central to plant development, and there are likely to be few aspects of development in which they are not involved. Understanding the developmental role of phytohormones is complicated, because each phytohormone controls so many responses. Furthermore, a single response is controlled by multiple hormones that may act either antagonistically or cooperatively. So far, the signaling pathways for the different plant hormones appear to be mostly independent of one another. This suggests that much of the integration of different signals may occur further downstream, at the level of gene regulation. Indeed, such integration has recently been shown for BR and auxin in the control of seedling growth (7), although a large number of genes seem to be regulated by BR or auxin independently (8). In addition, growth regulation by GA and auxin is, at least in part, integrated by activity of the DELLA proteins, which are putative transcriptional regulators (9). Identification of the key transcription factors controlled by each hormone and how they interact with each other and with their target genes will be crucial for understanding how phytohormones orchestrate plant development. The He et al. and Yin et al. studies are an important step in that direction.