Newborn screening for cystic fibrosis is associated with reduced treatment intensity
Newborn screening for cystic fibrosis is associated with reduced treatment intensity
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DOI：
10.1016/j.jpeds.2005.05.034
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发表时间：
2005-09-01
影响因子：
5.1
通讯作者：
Mehta, A
中科院分区：
文献类型：
--
作者：
Sims, EJ;McCormick, J;Mehta, A
目的探讨新生儿囊性纤维化（CF）筛查（NBS）后临床状况的改善与临床诊断（CD）表现相比，是否与增加治疗干预相分离。研究设计2002年，在观察性横断面设计中比较了两组（1 - 9岁）通过NBS（不包括胎便性肠梗阻）：3个月大或CD。NBS和CD人群（分别为184例和950例）分为3岁年龄组（1 ~ 3岁、4 ~ 6岁和7 ~ 9岁）。治疗时间bb0 ~ 3个月并与铜绿假单胞菌感染情况进行比较。NBS患者
Objectives To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD).Study design In 2002, two populations (1 to 9 years of age) who presented (excluding meconium ileus) by NBS: 3 months of age or by CD were compared in an observational, cross-sectional design. NBS and CD populations (184 and 950 patients, respectively) were divided into 3-year age groups (1 to 3, 4 to 6, and 7 to 9 years). Therapies of duration > 3 months were compared together with Pseudomonas aeruginosa infection status.Results NBS patients