ETHANOL HAS AN ACUTE EFFECT ON BILE-ACID BIOSYNTHESIS IN MAN
ETHANOL HAS AN ACUTE EFFECT ON BILE-ACID BIOSYNTHESIS IN MAN
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DOI：
10.1016/0014-5793(91)80382-d
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发表时间：
1991-04-09
期刊：
影响因子：
3.5
通讯作者：
SJOVALL, J
中科院分区：
文献类型：
--
作者：
AXELSON, M;MORK, B;SJOVALL, J
研究发现，单剂量乙醇（0.4 g/kg体重）可使人体中7-α-羟基胆固醇和7-α-羟基-4-胆甾烯-3-酮的血浆浓度增加5-15倍。 在摄入乙醇后4 h，升高最大，呈剂量依赖性，在胆囊切除受试者中未观察到。 该效应对胆汁酸生物合成中的这些和一些其他7-α-羟基化C27-中间体具有选择性。 这些变化与胆固醇7-α-羟化酶的急性刺激相容，可能是由于乙醇诱导的胆囊收缩抑制导致胆汁酸的肝肠循环中断。 该效应与乙醇消耗对心血管和胆结石疾病的影响有关。
A single dose of ethanol, 0.4 g/kg body weight, was found to give a 5-15 fold increase of the plasma concentration of 7-alpha-hydroxy-cholesterol and 7-alpha-hydroxy-4-cholesten-3-one in humans. The rise was maximal 4 h after ethanol ingestion, was dose-dependent and was not seen in a cholecystectomized subject. The effect was selective for these and some other 7-alpha-hydroxylated C27-intermediates in bile acid biosynthesis. The changes are compatible with an acute stimulation of cholesterol 7-alpha-hydroxylase possibly due to an ethanol-induced inhibition of gallbladder contraction resulting in an interuption of the enterohepatic circulation of bile acids. The effect is of interest in relation to the influence of ethanol consumption on cardiovascular and gallstone diseases.