THE HOMEOBOX GENE GOOSECOID AND THE ORIGIN OF ORGANIZER CELLS IN THE EARLY CHICK BLASTODERM
THE HOMEOBOX GENE GOOSECOID AND THE ORIGIN OF ORGANIZER CELLS IN THE EARLY CHICK BLASTODERM
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DOI：
10.1016/0092-8674(93)90512-o
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发表时间：
1993-08-27
期刊：
影响因子：
64.5
通讯作者：
STERN, CD
中科院分区：
文献类型：
--
作者：
IZPISUABELMONTE, JC;DEROBERTIS, EM;STERN, CD
鸡的同源异型盒基因goosecoid（gsc）首先在未孵化的蛋的后缘（科勒镰刀）附近的一个几乎不可见的细胞群中表达。然后在Hensen结中检测到它，传统上认为Hensen结是小鸡的组织者。随后，表达gsc的细胞随索前板离开淋巴结。命运作图表明这三个区域通过细胞谱系相关，并且移植实验表明它们都具有诱导活性。鹌鹑后缘和前原条移植物（表达gsc）诱导邻近鸡宿主细胞中gsc的转录。我们认为小鸡组织者的发育比以前认为的要早，gsc标志着细胞群的变化。
The chick homeobox gene goosecoid (gsc) is first expressed in a barely noticeable cell population near the posterior margin (Koller's sickle) of the unincubated egg. Then it is detected in Hensen's node, traditionally considered the chick organizer. Later, gsc-expressing cells leave the node with the prechordal plate. Fate mapping indicates that these three regions are related by cell lineage, and transplantation experiments suggest that they all have inducing activity. Quail posterior margin and anterior primitive streak grafts (gsc expressing) induce gsc transcription in neighboring chick host cells. We propose that development of the chick organizer starts earlier than previously thought and that gsc marks this changing cell population.