Population genomics and the bacterial species concept.
Population genomics and the bacterial species concept.
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DOI：
10.1007/978-1-60327-853-9_21
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发表时间：
2009
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近年来，水平基因转移(HGT)在细菌进化中的重要性已经提高到了如此程度，以至于许多细菌学家现在对细菌物种的存在提出了质疑。如果基因转移像比较基因组研究表明的那样猖獗，细菌物种如何在这样的基因组流动性中生存下来？然而，大多数细菌学家认识到，并将具有复杂表型特性的细菌分离物集群命名为物种。核心基因组假说(CGH)被提出来解释液体细菌基因组与稳定的表型簇相关的这一明显的悖论。它假设存在一个核心的基因，负责维持在整个细菌多样性中观察到的物种特有的表型簇，并认为，即使面对大量的基因组流动性，细菌物种也可以被合理地识别和命名。
In recent years, the importance of horizontal gene transfer (HGT) in bacterial evolution has been elevated to such a degree that many bacteriologists now question the very existence of bacterial species. If gene transfer is as rampant as comparative genomic studies have suggested, how could bacterial species survive such genomic fluidity? And yet, most bacteriologists recognize, and name, as species, clusters of bacterial isolates that share complex phenotypic properties. The Core Genome Hypothesis (CGH) has been proposed to explain this apparent paradox of fluid bacterial genomes associated with stable phenotypic clusters. It posits that there is a core of genes responsible for maintaining the species-specific phenotypic clusters observed throughout bacterial diversity and argues that, even in the face of substantial genomic fluidity, bacterial species can be rationally identified and named.