WHITE MATTER CHANGES IN DEMENTIA OF ALZHEIMERS TYPE - BIOCHEMICAL AND NEUROPATHOLOGICAL CORRELATES
WHITE MATTER CHANGES IN DEMENTIA OF ALZHEIMERS TYPE - BIOCHEMICAL AND NEUROPATHOLOGICAL CORRELATES
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DOI：
10.1093/brain/111.6.1425
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发表时间：
1988-12-01
期刊：
影响因子：
14.5
通讯作者：
ALLING, C
中科院分区：
文献类型：
--
作者：
ENGLUND, E;BRUN, A;ALLING, C
对阿尔茨海默病S型痴呆中常见的选择性不完全性白质梗塞进行了相关的神经病理-生化研究。在痴呆症患者中，主要是阿尔茨海默病和多发性梗死型脑组织，在患有脑梗塞的非痴呆者和年龄匹配的对照组中，分析的脑组织代表有不完全脑梗塞、完全脑梗塞和组织学正常组织的白质。生化结果证实了白质变化的存在，并与形态分析中出现的白质变化的区域分布一致。组织学评估的SIWI的严重性增加反映在几个生化量化的白质成分的比例减少上。不完全性和完全性脑梗塞之间的组织学差异也表现在生化方面。伴有和不伴有完全性脑梗塞的不完全性脑白质梗死在生化方面相似。讨论了不同脑白质成分丢失的病因学意义。生化数据支持SIWI是一种独立的脑血管、低灌注性/缺氧性白质障碍的概念。
A correlative neuropathological-biochemical study was undertaken in order to characterize the selective incomplete white matter infarctions (SIWI) frequently found in dementia of Alzheimer''s type. The brain tissue analysed represented white matter with incomplete infarction, complete infarcts and with histologically normal tissue, in cases with dementia, mainly of Alzheimer and multi-infarct type, in nondemented subjects with cerebral infarcts and in age-matched control cases. The biochemical results verify the existence of the white matter changes and agree on their regional distribution as they appear in the morphological analyses. The increasing severity of SIWI as assessed histologically reflected in a proportional reduction of several biochemically quantified white matter components. The histological difference between incomplete and complete infarction was also expressed biochemically. Incomplete white matter infarction with and without associated complete infarcts were biochemically similar. The aetiological significance of the loss of different white matter components is discussed. The biochemical data support the concept of SIWI as being an independent white matter disorder of cerebrovascular, hypoperfusional/hypoxic origin.