The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction
The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction
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DOI：
10.1111/1467-8624.00522
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发表时间：
2003-01-01
影响因子：
4.6
通讯作者：
Nadel, L
中科院分区：
文献类型：
--
作者：
Pennington, BF;Moon, J;Nadel, L
这项研究测试了 28 名学龄儿童的前额叶和海马功能（M = 14.7 岁，SD = 2.7）。患有唐氏综合症 (DS) 的个体与 28 名（M = 4.9 岁，SD = .75）正常发育儿童的心理年龄 (MA) 个体相匹配。两个神经心理学领域都通过多种行为测量进行了测试。言语和空间功能的基准测量表明，该 DS 样本与文献中的其他样本相似。主要发现是显着的组 x 域相互作用效应，表明 DS 组存在不同的海马功能障碍。然而，DS 组的海马和前额叶综合评分之间存在中度部分相关性（r = 0.54，控制实际年龄），并且这两种综合评分对该组的 MA 和适应行为的预测都有独特的方差。总之，这些结果表明，在整体认知功能障碍的背景下，DS 患者的海马功能特别薄弱。有趣的是，这些结果与 DS 小鼠模型中发现的结果相似。这样的模型将使人们更容易理解导致 DS 中海马功能障碍发生的神经生物学机制。
This study tested prefrontal and hippocampal functions in a sample of 28 school-aged (M = 14.7 years, SD = 2.7). individuals with Down syndrome (DS) compared with 28 (M = 4.9 years, SD = .75) typically developing children individually matched on mental age (MA). Both neuropsychological domains were tested with multiple behavioral measures. Benchmark measures of verbal and spatial function demonstrated that this DS sample was similar to others in the literature. The main finding was a significant Group x Domain interaction effect indicating differential hippocampal dysfunction in the group with DS. However, there was a moderate partial correlation (r = .54, controlling for chronological age) between hippocampal and prefrontal composite scores in the DS group, and both composites contributed unique variance to the prediction of MA and adaptive behavior in that group. In sum, these results indicate a particular weakness in hippocampal functions in DS in the context of overall cognitive dysfunction. It is interesting that these results are similar to what has been found in a mouse model of DS. Such a model will make it easier to understand the neurobiological mechanisms that lead to the development of hippocampal dysfunction in DS.