The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections.
The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections.
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DOI：
10.1017/s0950268812001823
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发表时间：
2013-06
影响因子：
4.2
通讯作者：
Parsonnet, J.
中科院分区：
文献类型：
--
作者：
Perry, S.;Chang, A. H.;Sanchez, L.;Yang, S.;Haggerty, T. D.;Parsonnet, J.
我们筛选了176名来自结核病流行国家的健康、成年(年龄18-55岁)的美国难民，以评估在幽门螺杆菌和蠕虫同时感染的情况下，细胞因子对潜伏性结核病感染(LTBI)的反应是否发生了改变。根据Quantiferon-TB金干扰素-γ释放试验的测量，共有38名(22%)受试者患有下腹部创伤，其中28名(74%)同时感染幽门螺杆菌和/或蠕虫。16例合并幽门螺杆菌感染的患者干扰素-γ水平显著升高，9例同时感染幽门螺杆菌和蠕虫的患者的干扰素-γ、IL-2、IL-13和IL-5水平显著升高。幽门螺杆菌与干扰素-γ对结核病的反应增强有关，即使在并发蠕虫感染的情况下也是如此。在发展中国家，由于这三种感染共存，结核病疫苗的效力可能会有所不同。
We screened 176 healthy, adult (aged 18–55 years) US refugees from tuberculosis (TB)-endemic countries to evaluate whether cytokine responses to latent TB infection (LTBI) are modified in the setting of concurrent H. pylori and helminth infection. As measured by the Quantiferon-TB GOLD interferon-γ release assay, a total 38 (22%) subjects had LTBI, of which 28 (74%) also were H. pylori seropositive and/or helminth infected. Relative to ten subjects with LTBI only, 16 subjects with concurrent H. pylori infection had significantly elevated levels of IFN-γ, and nine subjects with both H. pylori and helminth infection had significantly elevated levels of IFN-γ, IL-2, IL-13, and IL-5. H. pylori is associated with enhanced IFN-γ responses to TB, even in the setting of concurrent helminth infection. Efficacy of TB vaccines may vary with the co-existence of these three infections in the developing world.