Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrier.
Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrier.
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DOI：
10.1111/j.1749-6632.1988.tb51417.x
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发表时间：
1988-01-01
影响因子：
5.2
通讯作者：
Goldstein, G W
中科院分区：
文献类型：
--
作者：
Goldstein, G W
大脑中的微血管内皮细胞具有许多特殊特性，这些特性是血脑屏障（BBB）形成的基础，并有助于控制神经元微环境。移植实验的证据表明，大脑内产生的信号而不是内皮细胞的程序化承诺负责血脑屏障特性的表达。脑内皮细胞和星形胶质细胞足突之间的密切解剖关系表明星形胶质细胞作为分化信号源的作用。现在可以分离并单独培养脑源性内皮细胞和星形胶质细胞群。当两种细胞类型一起生长时，会出现一种特征性的形态组织，该形态组织与酶的诱导和与体内发现的紧密连接类似。培养中的内皮细胞和星形胶质细胞在特定多肽生长因子的产生和反应方面有所不同。这些发现为内皮细胞-星形胶质细胞相互作用模型提供了基础，该模型可以解释 BBB 行为的几个方面。
Microvascular endothelial cells in the brain have a number of special properties that underlie formation of the blood-brain barrier (BBB) and contribute to control of the neuronal microenvironment. Evidence from transplantation experiments indicates that signals arising within brain rather than a programmed commitment of the endothelial cells are responsible for the expression of blood-brain barrier properties. The close anatomic relationship between brain endothelial cells and the foot processes of astrocytes suggests a role for astrocytes as a source of the differentiation signals. It is now possible to isolate and separately culture populations of brain-derived endothelial cells and astrocytes. When the two cell types are grown together, a characteristic morphologic organization occurs that is associated with induction of enzymes and tight junctions similar to those found in vivo. Endothelial cells and astrocytes in culture differ in their production of and response to specific polypeptide growth factors. These findings provide the basis for a model of endothelial cell-astrocyte interaction that may explain several aspects of BBB behavior.