INVIVO EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTALLY INDUCED NEUROLOGIC DISEASES
INVIVO EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN EXPERIMENTALLY INDUCED NEUROLOGIC DISEASES
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DOI：
10.1073/pnas.90.7.3024
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发表时间：
1993-04-01
影响因子：
11.1
通讯作者：
DIETZSCHOLD, B
中科院分区：
文献类型：
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作者：
KOPROWSKI, H;ZHENG, YM;DIETZSCHOLD, B
本研究的目的是探讨在下列实验条件下，诱导型一氧化氮合酶（iNOS）mRNA在大鼠和小鼠脑组织中的诱导：在大鼠感染博尔纳病病毒和狂犬病病毒，在小鼠感染单纯疱疹病毒，并在大鼠诱发实验性变态反应性脑炎后。结果表明，iNOS mRNA，通常在大脑中检测不到，存在于病毒感染或诱导实验性过敏性脑炎后的动物。iNOS mRNA的诱导与临床体征的严重程度相一致，在某些情况下，与脑中炎性细胞的存在相一致。结果提示，iNOS诱导细胞产生的NO可能是导致细胞损伤的毒性因子，这为神经系统疾病的发病机制研究提供了新的途径。
The purpose of this study was to investigate the induction of inducible nitric oxide synthase (iNOS) mRNA in the brain tissue of rats and mice under the following experimental conditions: in rats infected with borna disease virus and rabies virus, in mice infected with herpes simplex virus, and in rats after the induction of experimental allergic encephalitis. The results showed that iNOS mRNA, normally nondetectable in the brain, was present in animals after viral infection or after induction of experimental allergic encephalitis. The induction of iNOS mRNA coincided with the severity of clinical signs and in some cases with the presence of inflammatory cells in the brain. The results indicate that nitric oxide produced by cells induced by iNOS may be the toxic factor accounting for cell damage and this may open the door to approaches to the study of the pathogenesis of neurological diseases.