Dendritic cells change IL-27 production pattern during childhood.
Dendritic cells change IL-27 production pattern during childhood.
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DOI：
10.1186/s13104-015-1182-0
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发表时间：
2015-06-09
影响因子：
1.8
通讯作者：
Knuf, Markus
中科院分区：
文献类型：
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作者：
Meyer, Claudius U;Birkholz, Julia;Knuf, Markus
背景：白细胞介素-27 （IL-27）在出生后的第一天被描述为高表达，但在儿童时期树突状细胞分泌IL-27尚未被描述。在我们目前的研究中，我们招募了1天至18岁的儿童（n = 55），并要求采集少量全血样本。在有或没有炎症刺激的全血培养后，测量儿童时期树突状细胞产生IL-27的能力。结果支持最近的研究结果，出生后IL-27水平高，成人IL-27水平低。有趣的是，我们在青春期早期发现了一个临时的生产高峰。结论：这些数据提示IL-27在出生后生命开始时的重要作用。此外，到目前为止尚未描述的青春期免疫事件也有关联。
BACKGROUND: Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described.FINDINGS: In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age and asked for a small whole blood sample. The capacity of dendritic cells to produce IL-27 during childhood was measured after whole blood culture with or without inflammatory stimuli. Results support recent findings of high IL-27 levels after birth and lowest levels in adults. Interestingly, we detected an interim peak production level at early adolescence.CONCLUSION: These data hint to prominent roles of IL-27 at the very start of post-natal life. Furthermore, a link has been given to so far not described immunological events during puberty.