Diamond electrodes for neurodynamic studies in Aplysia californica
Diamond electrodes for neurodynamic studies in Aplysia californica
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DOI：
10.1016/j.diamond.2005.06.039
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发表时间：
2006-02-01
影响因子：
4.1
通讯作者：
Martin, HB
中科院分区：
文献类型：
--
作者：
Halpern, JM;Xie, ST;Martin, HB
作为一项正在进行的努力的一部分，证明金刚石是一种用于生物应用的多功能电极材料，我们介绍了在动物模型中用于神经动力学研究的金刚石电极的发展进展。Diamond提供了一个独特的机会，将神经刺激和传感整合到同一个植入式装置中。数据从几个平行研究提出：在体外测量血清素浓度，测量电活动和神经刺激。利用金刚石微电极，研究了加利福尼亚海杉进食模式的变化与血清素浓度的关系，血清素可以作为进食行为的神经调节剂。(c) 2005 Elsevier B.V.版权所有
As part of an ongoing effort to demonstrate that diamond is a versatile electrode material for biological applications, we present our progress in the development of diamond electrodes for the study of neurodynamics in an animal model, Aplysia californica. Diamond provides a unique opportunity to integrate neural stimulation and sensing in the same implantable device. Data from several parallel studies are presented: in vitro measurement of serotonin concentration, measurement of electrical activity, and neural stimulation. Using diamond microelectrodes, changes of the Aplysia californica's feeding patterns are being studied as a function of concentration of serotonin, which can act as a neuromodulator of feeding behavior. (c) 2005 Elsevier B.V. All rights reserved.