Acute effect of infection by adipogenic human adenovirus Ad36.
Acute effect of infection by adipogenic human adenovirus Ad36.
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DOI：
10.1007/s00705-008-0219-2
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发表时间：
2008
影响因子：
2.7
通讯作者：
Dhurandhar, Nikhil V.
中科院分区：
文献类型：
--
作者：
Pasarica, Magdalena;Loiler, Scott;Dhurandhar, Nikhil V.
人腺病毒Ad36分别在动物和人类中与肥胖增加和代谢谱改变有因果关系和相关关系。我们分别给大鼠接种Ad36、uv灭活Ad36或模拟感染。4天后，感染ad36的大鼠附睾脂肪垫重量和病毒mRNA均增加23%，肝、脑和脂肪组织中也检测到病毒DNA。鼻内或腹膜内途径的病毒接种显示相似的组织亲和力。血清细胞因子反应明显下调。Ad36急性抑制全身免疫反应并广泛传播。这一信息将有助于确定Ad36的组织趋向性及其代谢后果。
Human adenovirus Ad36 is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. We inoculated rats with Ad36, UV-inactivated Ad36 or mock-infected. Four-days later, Ad36-infected rats showed 23% greater epididymal fat pad weight and viral mRNA, the viral DNA could also be detected in tissues viz. the liver, brain, and adipose tissue. Intranasal or intra-peritoneal routes of viral inoculations showed similar tissue affinity. Serum cytokine response was remarkably down regulated. Ad36 acutely suppresses systemic immune response and spreads widely. This information will help to determine Ad36 tissue tropism and its metabolic consequences.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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Iacobelli-Martinez, M;Nepomuceno, RR;Nemerow, GR
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作者：
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通讯作者：
SHERIKAR, A