Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19.
Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19.
复制标题
DOI：
10.1038/s41598-021-99481-9
复制
发表时间：
2021-10-12
影响因子：
4.6
通讯作者：
Xia Z
中科院分区：
文献类型：
--
作者：
Le TT;Gutiérrez-Sacristán A;Son J;Hong C;South AM;Beaulieu-Jones BK;Loh NHW;Luo Y;Morris M;Ngiam KY;Patel LP;Samayamuthu MJ;Schriver E;Tan ALM;Moore J;Cai T;Omenn GS;Avillach P;Kohane IS;Consortium for Clinical Characterization of COVID-19 by EHR (4CE);Visweswaran S;Mowery DL;Xia Z
神经系统并发症恶化了COVID-19的结局。为了确定在大流行早期，在地理位置不同的多国人群中，SARS-CoV-2逆转录聚合酶链反应检测阳性的住院患者中神经系统疾病的患病率，我们使用了来自6个国家和3大洲（2020年1月至9月）的338家参与医院的电子健康记录（EHR）进行了横断面分析。我们按国家、医疗系统、COVID-19入院前后时间和COVID-19严重程度评估了神经系统疾病的国际疾病分类代码的频率。在35，177例SARS-CoV-2感染住院患者中，与入院前比例相比，意识障碍（5.8%，95%置信区间[CI] 3.7- 7.8%，pFDR < 0.001）和未指明的脑部疾病（8.1%，5.7- 10.5%，pFDR < 0.001）的比例增加。住院期间，意识障碍的相对风险（22%，19-25%），脑血管疾病（24%，13-35%），非创伤性颅内出血（34%，20-50%），脑炎和/或脑炎与从未经历过严重COVID-19的患者相比，患有严重COVID-19的患者的患病率（37%，17-60%）和肌病（72%，67-77%）更高。利用跨国网络获取标准化EHR数据，我们强调了因COVID-19住院的患者，特别是重症患者中中枢和外周神经系统表型的患病率增加。
Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.
登录
查看更多内容
影响因子：
5.1
作者：
Cosentino G;Todisco M;Hota N;Della Porta G;Morbini P;Tassorelli C;Pisani A
通讯作者：
Pisani A
影响因子：
13.8
作者：
Bourgeois FT;Gutiérrez-Sacristán A;Keller MS;Liu M;Hong C;Bonzel CL;Tan ALM;Aronow BJ;Boeker M;Booth J;Cruz Rojo J;Devkota B;García Barrio N;Gehlenborg N;Geva A;Hanauer DA;Hutch MR;Issitt RW;Klann JG;Luo Y;Mandl KD;Mao C;Moal B;Moshal KL;Murphy SN;Neuraz A;Ngiam KY;Omenn GS;Patel LP;Jiménez MP;Sebire NJ;Balazote PS;Serret-Larmande A;South AM;Spiridou A;Taylor DM;Tippmann P;Visweswaran S;Weber GM;Kohane IS;Cai T;Avillach P;Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
通讯作者：
Consortium for Clinical Characterization of COVID-19 by EHR (4CE)
影响因子：
11.2
作者：
Fragiel, Marcos;Miro, Oscar;Gonzalez del Castillo, Juan
通讯作者：
Gonzalez del Castillo, Juan
影响因子：
8.4
作者：
Bagnato, Sergio;Boccagni, Cristina;Rubino, Francesca
通讯作者：
Rubino, Francesca
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA