Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans
Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans
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DOI：
10.1007/s00421-012-2413-x
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发表时间：
2012-05
影响因子：
3
通讯作者：
Naoto Fujii;M. Ichinose;Y. Honda;B. Tsuji;Kazuhito Watanabe;N. Kondo;T. Nishiyasu
中科院分区：
文献类型：
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作者：
Naoto Fujii;M. Ichinose;Y. Honda;B. Tsuji;Kazuhito Watanabe;N. Kondo;T. Nishiyasu
在静止状态下，动脉血压和对严重被动加热的通气反应在个体之间差异很大。我们测试了一个假设，即在休息的人类严重被动加热期间，通气的增加与动脉血压的降低有关。对18名健康男性进行被动加热，使用热水浸泡至髂骨水平，并穿着水灌注服。然后我们将受试者分为两组：MAPNOTINC组（n= 8）和MAPINC组（n= 10）， MAPNOTINC组在加热结束时平均动脉血压（MAP）升高≤3mmhg。加热引起的食管温度（Tes）升高在两组中相似（+2.3±0.3°C vs +2.4±0.4°C）。在加热初期（升高温度<1.5°C）， MAP、分钟通气量（）和潮末co2压力（）在各组之间相似。而在升温后期（升温幅度≥1.5℃），升温幅度和降温幅度均显著大于或趋于更大，而mapnotincs的升温幅度明显小于mapincs。在所有被试中，加热引起的MAP变化与加热引起的MAP变化呈不显著负相关（r= - 0.52 ~ - 0.74，P< 0.05）。这些结果表明，在静息状态下，25 - 50%的动脉血压对严重被动加热反应的幅度变化可以用高温诱导的过度通气的幅度来解释。
The arterial blood pressure and ventilatory responses to severe passive heating at rest varies greatly among individuals. We tested the hypothesis that the increase in ventilation seen during severe passive heating of resting humans is associated with a decrease in arterial blood pressure. Passive heating was performed on 18 healthy males using hot water immersion to the level of the iliac crest and a water-perfused suit. We then divided the subjects into two groups: MAPNOTINC(n= 8), whose mean arterial blood pressure (MAP) at the end of heating had increased by ≤3 mmHg, and MAPINC(n= 10), whose MAP increased by >3 mmHg. Increases in esophageal temperature (Tes) elicited by the heating were similar in the two groups (+2.3 ± 0.3 vs. +2.4 ± 0.4 °C). Early during heating (increase inTeswas <1.5 °C), MAP, minute ventilation (), and end-tidal CO2pressure () were similar between the groups. However, during the latter part of heating (increase inTeswas ≥1.5 °C), the increase inand decrease inwere significantly greater or tended to be greater, while the increase in MAP was significantly smaller in MAPNOTINCthan MAPINC. Among all subjects, heating-induced changes insignificantly and negatively correlated with heating-induced changes in MAP during the latter part of heating (r= −0.52 to −0.74,P< 0.05). These results suggest that, in resting humans, 25−50 % of the variation in the magnitude of the arterial blood pressure response to severe passive heating can be explained by the magnitude of hyperthermia-induced hyperventilation.