RCAS1 expression as a prognostic factor after curative surgery for extrahepatic bile duct carcinoma
RCAS1 expression as a prognostic factor after curative surgery for extrahepatic bile duct carcinoma
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RCAS1 表达作为肝外胆管癌根治性手术后的预后因素
作者：
M. Suzuoki;Y. Hida;M. Miyamoto;T. Oshikiri;K. Hiraoka;Y. Nakakubo;T. Shinohara;T. Itoh;S. Okushiba;S. Kondo;H. Katoh
研究背景RCAS 1（receptor-binding cancer antigen expressed on SiSo cells）是一种癌细胞表面抗原，被认为是多种癌症的预后因子。据认为，肿瘤细胞通过表达RCAS 1来逃避免疫攻击，RCAS 1诱导受体阳性免疫细胞的凋亡。方法采用免疫组化法检测1992 ~ 1999年60例肝外胆管癌（EBDC）患者RCAS 1的表达，并分析其与临床病理特征及预后的关系。根据RCAS 1表达的程度将患者分为两组：低表达组（免疫反应性<25%的细胞）和高表达组。结果RCAS 1在60例乳腺癌中的表达率为86.7%（52/60），在各期乳腺癌中的表达率较高。60例乳腺癌中46例（76.7%）RCAS 1高表达。RCAS 1的表达模式与任何临床病理特征之间不存在相关性，尽管高表达确实与不良预后相关。结论RCAS 1高表达是可切除EBDC预后不良的独立预测因子。
BackgroundRCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a cancer cell-surface antigen and has been identified as a prognostic factor in several cancers. It is thought that tumor cells escape from immune attack by expressing RCAS1, which induces apoptosis in receptor-positive immune cells. We investigated the relationship between RCAS1 expression and clinicopathologic features and clinical outcome in patients with extrahepatic bile duct carcinoma (EBDC) who underwent curative resection.MethodsRCAS1 expression was determined by immunohistochemistry in 60 patients with EBDC who underwent curative resection from 1992 to 1999. The patients were divided into two groups on the basis of the extent of RCAS1 expression: a low-expression group (immunoreactivity in <25% of cells) and a high-expression group. Expression was correlated with clinicopathologic features and prognosis.ResultsRCAS1 was expressed in 52 (86.7%) of 60 tumors and at a high frequency in all histopathologic stages. High expression of RCAS1 was detected in 46 (76.7%) of 60 cases. No correlation existed between the pattern of RCAS1 expression and any clinicopathologic feature, although high expression did correlate with poor prognosis. High RCAS1 expression was an independent negative predictor for survival.ConclusionsRCAS1 expression predicts poor outcome in resectable EBDC.