Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: a randomized controlled trial
Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: a randomized controlled trial
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DOI：
10.3945/ajcn.115.123463
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发表时间：
2017-01-01
影响因子：
7.1
通讯作者：
Mellgren, Gunnar
中科院分区：
文献类型：
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作者：
Veum, Vivian L.;Laupsa-Borge, Johnny;Mellgren, Gunnar
背景资料：饮食模式的不同方面，包括大量营养素和食物概况，可能会影响内脏脂肪质量和代谢综合征。目的：我们假设，在具有相似食物概况的饮食中，主要从碳水化合物或脂肪消耗能量，会不同程度地影响逆转内脏脂肪和代谢综合征的能力。设计：46个人（30-50岁），体重指数（以kg/m2计）>29和腰围>98 cm的受试者被随机分配到一个非常高脂肪、低碳水化合物（VHFLC; 73%的能量脂肪和10%的能量碳水化合物）或低脂高碳水化合物（LFHC; 30%的能量脂肪和53%的能量碳水化合物）饮食12周。饮食中的能量（8750千焦/天），蛋白质（17%的能量）和食物的配置文件是平等的，强调低加工，低血糖的食物。脂肪质量定量与计算机断层成像imaging.Results：记录摄入的碳水化合物和总脂肪和饱和脂肪的LFHC和VHFLC组分别为51%和11%的能量，29%和71%的能量，和12%和34%的能量，分别与蛋白质和多不饱和脂肪酸没有差异。LFHC和VHFLC组的平均能量摄入量分别减少了22%和14%。饮食同样减少腰围（11-13 cm），腹部皮下脂肪量（1650-1850 cm（3）），内脏脂肪量（1350-1650 cm（3））和总体重（11-12 kg）。两组均改善了血脂异常，降低了循环甘油三酯，但在总胆固醇和低密度脂蛋白胆固醇（仅LFHC组降低）以及高密度脂蛋白胆固醇（仅VHFLC组升高）方面表现出不同的反应。两组在胰岛素、胰岛素C肽、糖化血红蛋白和胰岛素抵抗的稳态模型评估方面表现出相似的降低。值得注意的是，在VHFLC组的循环代谢指标的改善主要是观察到第一个8周后，在LFHC group.Conclusions：消耗能量主要是碳水化合物或脂肪3个月没有差异影响内脏脂肪和代谢综合征在低加工，低血糖饮食背景下，更急性和渐进的影响。我们的数据并不支持膳食脂肪本身会促进人类异位肥胖和心脏代谢综合征的观点。
Background: Different aspects of dietary pattern, including macronutrient and food profiles, may affect visceral fat mass and metabolic syndrome.Objective: We hypothesized that consuming energy primarily from carbohydrate or fat in diets with similar food profiles would differentially affect the ability to reverse visceral adiposity and metabolic syndrome.Design: Forty-six men (aged 30-50 y) with body mass index (in kg/m(2)) >29 and waist circumference >98 cm were randomly assigned to a very high fat, low-carbohydrate (VHFLC; 73% of energy fat and 10% of energy carbohydrate) or low-fat, high-carbohydrate (LFHC; 30% of energy fat and 53% of energy carbohydrate) diet for 12 wk. The diets were equal in energy (8750 kJ/d), protein (17% of energy), and food profile, emphasizing low-processed, lower-glycemic foods. Fat mass was quantified with computed tomography imaging.Results: Recorded intake of carbohydrate and total and saturated fat in the LFHC and VHFLC groups were 51% and 11% of energy, 29% and 71% of energy, and 12% and 34% of energy, respectively, with no difference in protein and polyunsaturated fatty acids. Mean energy intake decreased by 22% and 14% in the LFHC and VHFLC groups. The diets similarly reduced waist circumference (11-13 cm), abdominal subcutaneous fat mass (1650-1850 cm(3)), visceral fat mass (1350-1650 cm(3)), and total body weight (11-12 kg). Both groups improved dyslipidemia, with reduced circulating triglycerides, but showed differential responses in total and low-density lipoprotein cholesterol (decreased in LFHC group only), and high-density lipoprotein cholesterol (increased in VHFLC group only). The groups showed similar reductions in insulin, insulin C-peptide, glycated hemoglobin, and homeostasis model assessment of insulin resistance. Notably, improvements in circulating metabolic markers in the VHFLC group mainly were observed first after 8 wk, in contrast to more acute and gradual effects in the LFHC group.Conclusions: Consuming energy primarily as carbohydrate or fat for 3 mo did not differentially influence visceral fat and metabolic syndrome in a low-processed, lower-glycemic dietary context. Our data do not support the idea that dietary fat per se promotes ectopic adiposity and cardiometabolic syndrome in humans.