DOSE ESTIMATION SOFTWARE FOR RADIATION BIODOSIMETRY
DOSE ESTIMATION SOFTWARE FOR RADIATION BIODOSIMETRY
复制标题
DOI：
10.1097/01.hp.0000346305.84577.b4
复制
发表时间：
2010-02-01
期刊：
影响因子：
2.2
通讯作者：
Lloyd, David C.
中科院分区：
文献类型：
--
作者：
Ainsbury, Elizabeth A.;Lloyd, David C.
血淋巴细胞染色体损伤的细胞遗传学分析被广泛用于辐射生物剂量学。数学和统计分析对于数据和结果的准确评估极其重要，并且有许多常规使用的经典统计方法。然而，大量不同的数学技术，模型对某些统计原则的依赖，以及某些方法的复杂性，可能会导致数据分析中的错误，从而导致对结果的误解。已开发了细胞遗传学剂量估算软件，通过简化细胞遗传学数据的数学和统计分析来解决这些问题。“剂量估计”是基于细胞遗传学方法的数学和统计方法的集合，用于健康保护局和辐射细胞遗传学界其他地方的生物剂量测定。详细的生物和数学工具纳入软件。已经进行了初步测试，测试结果表明该软件目前的形式是准确和有用的。还概述了通过实施最近发表的细胞遗传学贝叶斯分析技术改进软件的建议。该软件的评估副本可应作者的要求提供。健康物理98（2）：290-295; 2010
Cytogenetic analysis of chromosome damage in blood lymphocytes is widely used for radiation biodosimetry. Mathematical and statistical analysis is extremely important for accurate assessment of the data and results, and there are a number of classical statistical methods which are routinely employed. However, the large number of different mathematical techniques, the dependence of the models on certain statistical principles, and the complexity of some of the methods can lead to errors in data analysis and thus misinterpretation of results. Cytogenetic dose estimation software has been developed to address these problems by simplifying mathematical and statistical analysis of the cytogenetic data. "Dose Estimate" is a collection of mathematical and statistical methods based on the cytogenetic methods that are used for biodosimetry at the Health Protection Agency and elsewhere in the radiation cytogenetics community. Details of the biological and mathematical tools incorporated into the software are presented. Preliminary testing has been carried out, and the results demonstrate the accuracy and usefulness of the software in its current form. Proposals for improving the software through implementation of recently published Bayesian analysis techniques for cytogenetics are also outlined. An evaluation copy of the software is available on request from the authors. Health Phys. 98(2):290-295; 2010