Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes.
Association of serum Cyr61 levels with peripheral arterial disease in subjects with type 2 diabetes.
复制标题
2 型糖尿病患者血清 Cyr61 水平与外周动脉疾病的关系
DOI：
10.1186/s12933-020-01171-9
复制
发表时间：
2020-11-22
影响因子：
9.3
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Feng B;Xu G;Sun K;Duan K;Shi B;Zhang N
背景糖尿病患者外周动脉疾病（peripheral artery disease，PAD）的患病率明显增高.富含半胱氨酸的血管生成诱导因子61（Cyr61）是一种分子量为40 kD的分泌蛋白，在调节细胞生理过程中发挥重要作用。最近的研究表明血清Cyr 61与动脉粥样硬化之间存在显著的相关性。然而，Cyr61水平和PAD在2型糖尿病（T2DM）患者之间的关系仍然模糊。MethodsData从共306例T2DM进行了横断面分析。PAD的程度通过使用方丹分类法确定，该分类法定义了四个阶段。我们通过ELISA法测定了方丹II、III或IV期PAD患者和非PAD患者的血清Cyr 61浓度。Logistic回归模型被用来检查的独立关联Cyr61与PAD.ResultsOut的306例受试者入组，150例是免费的PAD，而156有临床意义的PAD。在PAD受试者中，方丹分级II、III和IV期的患病率分别为48.7%、32.1%和19.2%。晚期PAD患者Cyr 61显著增高（P < 0.001）。PAD的患病率随Cyr 61四分位数的增加而增加（P < 0.001），PAD的严重程度与Cyr 61四分位数呈正相关（r = 0.227，P = 0.006）。调整后的主要危险因素在logistic回归analys.ConclusionsOur结果表明，Cyr61与PAD水平的关联仍然是PAD患者与T2DM和Cyr61水平显着增加与疾病的严重程度呈正相关。Cyr61可能是一个有前途的生物标志物，需要进一步的研究来评估其临床实用性。
BackgroundThe prevalence of peripheral artery disease (PAD) is obviously increased in patients with diabetes. Existing evidence shows that cysteine-rich angiogenic inducer 61 (Cyr61), a 40-kD secreted protein, plays important roles in regulating cellular physiological processes. Recent studies have demonstrated a significant correlation between serum Cyr61 and atherosclerosis. However, the relationship between Cyr61 levels and PAD in patients with type 2 diabetes (T2DM) remains obscure.MethodsData from a total of 306 subjects with T2DM were cross-sectionally analysed. The extent of PAD was determined by using the Fontaine classification, which defines four stages. We measured serum Cyr61 concentrations by ELISA in subjects with and without PAD at Fontaine’s stage II, III, or IV. Logistic regression models were used to examine the independent association of Cyr61 with PAD.ResultsOut of the 306 subjects enrolled, 150 were free from PAD, while 156 had clinically significant PAD. In subjects with PAD, the prevalences of Fontaine classification stages II, III and IV were 48.7%, 32.1%, and 19.2%, respectively. Patients with more advanced PAD had significantly higher Cyr61 (Pfor trend < 0.001). The prevalence of PAD on the basis of severity increased with increasing Cyr61 quartiles (allPvalues for trends < 0.001), and the severity of PAD was positively correlated with Cyr61 quartiles (r = 0.227,P= 0.006). The association of Cyr61 levels with PAD remained after adjusting for major risk factors in a logistic regression analysis.ConclusionsOur results demonstrated that Cyr61 was significantly increased in PAD patients with T2DM and that Cyr61 levels were positively associated with disease severity. Cyr61 could be a promising biomarker and further studies are needed to assess its clinical utility.
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影响因子：
8.2
作者：
Hughes, J. M.;Kuiper, E. J.;Klaassen, I.;Canning, P.;Stitt, A. W.;Van Bezu, J.;Schalkwijk, C. G.;Van Noorden, C. J. F.;Schlingemann, R. O.
通讯作者：
Schlingemann, R. O.
影响因子：
39.3
作者：
Klingenberg, Roland;Aghlmandi, Soheila;Luscher, Thomas F.
通讯作者：
Luscher, Thomas F.
DOI：
10.1161/atvbaha.108.162362
发表时间：
2008-06-01
影响因子：
8.7
作者：
Matsumae, Hironobu;Yoshida, Yoshinori;Tanaka, Makoto
通讯作者：
Tanaka, Makoto
影响因子：
5.8
作者：
Deruaz-Luyet, Anouk;Raabe, Christina;Lavery, Lawrence A.
通讯作者：
Lavery, Lawrence A.
影响因子：
20.1
作者：
Lee, Hae-Young;Chung, Jae-Woong;Kim, Hyo-Soo
通讯作者：
Kim, Hyo-Soo