Effect of neuropeptides on production of inflammatory cytokines by human monocytes.
Effect of neuropeptides on production of inflammatory cytokines by human monocytes.
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DOI：
10.1097/00006454-198907000-00033
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发表时间：
1989-07
期刊：
影响因子：
56.9
通讯作者：
M. Lotz;J. Vaughan;D. Carson
中科院分区：
文献类型：
--
作者：
M. Lotz;J. Vaughan;D. Carson
神经肽P物质和K物质以及单核细胞衍生的细胞因子这两类介质在免疫和炎症反应的神经调节中相互作用。P物质、K物质和羧基末端多肽SP(4-11)可诱导人单核细胞释放白介素1、肿瘤坏死因子α和白介素6。神经肽效应在低剂量下发生，P物质拮抗剂的抑制研究表明它是特异的，需要从头合成蛋白质。由于单核细胞衍生的细胞因子在炎症和免疫中调节多种细胞功能，而且神经肽可以从周围神经末梢释放到周围组织，这些发现证实了神经系统调节宿主防御反应的有效机制。
Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived cytokines, interact in the neural regulation of immunological and inflammatory responses. Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-alpha, and interleukin-6 from human blood monocytes. The neuropeptide effects occur at low doses, are specific as shown by inhibition studies with a substance P antagonist, and require de novo protein synthesis. Since monocyte-derived cytokines regulate multiple cellular functions in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surrounding tissues, these findings identify a potent mechanism for nervous system regulation of host defense responses.